Compatibility «Bendazol+Metamizole sodium+Papaverine+Phenobarbital» and «Parcocet»

• Interactions Bendazol+Metamizole sodium+Papaverine+Phenobarbital with Parcocet

  • Dangerous interactions
    • ⓘ Simultaneous use with other antipyretic analgesics, NSAIDs can lead to a mutual increase in toxic effects, with chlorpromazine or other phenothiazine derivatives - to the development of severe hyperthermia.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
    • ⓘ Phenobarbital (N03AA02) + Opioid narcotic analgesics (N02A) => Dangerous inhibition. (Avoid simultaneous use).
    • ⓘ Opioid narcotic analgesics (N01AH01) + CNS depressants; hypnotics, neuroleptics, benzodiazepine tranquilizers, etc. => Respiratory depression, bradycardia, deep coma, possible death.
  • Negative interactions
    • ⓘ The simultaneous use of sodium metamizole with other non-narcotic analgesics may lead to a mutual increase in toxic effects.
    • ⓘ Therefore, this combination should be used with caution in the treatment of patients taking low doses of acetylsalicylic acid for cardioprotection (prevention of thrombosis).
    • ⓘ Metamizole sodium and Acetylsalicylic acid belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ With simultaneous use, sodium metamizole can reduce the effect of acetylsalicylic acid on platelet aggregation, therefore, this combination should be used with caution in patients receiving acetylsalicylic acid in low doses for cardioprotection.
    • ⓘ Metamizole sodium and Paracetamol belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Salicylates (N02BA) + Phenobarbital => Weakening of anti-inflammatory, analgesic, antipyretic and other types of pharmacological action of salicylates.
  • No interactions
    • ⓘ When used together, sodium metamizole can reduce the effect of acetylsalicylic acid on platelet aggregation.
    • ⓘ Hypnotics; Sedatives (N05C) + Respiratory stimulants (R07AB, N06BC) => Respiratory analeptics are used for poisoning with hypnotics and sedatives..
  • Positive interactions
    • ⓘ With codeine, H₂‑histamine receptor blockers and propranolol: codeine, H₂‑histamine receptor blockers and propranolol enhance the effects of sodium metamizole.
    • ⓘ The effect is enhanced by barbiturates, codeine, caffeine, H₂-antihistamines, propranolol (slows down inactivation).
    • ⓘ Codeine, H₂-histamine receptor blockers and propranolol enhance the effects of sodium metamizole.
    • ⓘ Antiepileptic drugs + Butadione, salicylates => Increased action of diphenine.
  • Unclear interactions
    • ⓘ With other non-narcotic analgesics.
    • ⓘ With acetylsalicylic acid (ASA).
    • ⓘ With acetylsalicylic acid.
    • ⓘ Metamizole sodium + Acetylsalicylic acid analgin and citramon are used together in Антигриппин аптекарский.
    • ⓘ Sodium metamizole.
    • ⓘ With codeine, H₂-histamine receptor blockers and propranolol.
    • ⓘ Metamizole sodium + Codeine analgin and citramon are used together in 13 preparations.
    • ⓘ Metamizole sodium + Caffeine analgin and citramon are used together in 18 preparations.
    • ⓘ Metamizole sodium + Paracetamol analgin and citramon are used together in 7 preparations.
    • ⓘ Papaverine + Codeine analgin and citramon are used together in Omnopon, Spasmoveralgin Neo.
    • ⓘ Papaverine + Caffeine analgin and citramon are used together in ПАГЛЮВЕРИН-2, Pagluferalum, ПАГЛЮВЕРИН-3.
    • ⓘ Phenobarbital + Codeine analgin and citramon are used together in 16 preparations.
    • ⓘ Phenobarbital + Caffeine analgin and citramon are used together in 22 preparations.
    • ⓘ Phenobarbital + Paracetamol analgin and citramon are used together in 10 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,999,821 possible combinations of drugs and their components were found 412,536 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-02-20

Category - medicine