Compatibility «Tramadol» and «Ibuprofen+Codeine+Caffeine+Metamizole sodium+Phenobarbital»

• Interactions Tramadol with Ibuprofen+Codeine+Caffeine+Metamizole sodium+Phenobarbital

  • Dangerous interactions
    • ⓘ Reduces the effectiveness of narcotic and hypnotic drugs, increases the excretion of lithium preparations in the urine; accelerates absorption and enhances the effect of cardiac glycosides, increases their toxicity.
    • ⓘ Codeine (R05DA04) + Opioid narcotic analgesics (N02A) => Dangerous inhibition. (Avoid simultaneous use).
    • ⓘ Opioid narcotic analgesics (N02A) + Respiratory stimulants (R07AB, N06BC) => With the combined use of opioid analgesics (in high doses) and respiratory analeptics, seizures may develop.
    • ⓘ Respiratory analeptics (R07A_B) + Narcotic analgesics => Convulsive syndrome may occur.
    • ⓘ It enhances the effect of drugs that depress the central nervous system (in pm, tranquilizers, hypnotics, sedatives and anesthetics), and ethanol.
    • ⓘ Opioid narcotic analgesics (N01AH01) + CNS depressants; hypnotics, neuroleptics, benzodiazepine tranquilizers, etc. => Respiratory depression, bradycardia, deep coma, possible death.
    • ⓘ Phenobarbital (N03AA02) + Opioid narcotic analgesics (N02A) => Dangerous inhibition. (Avoid simultaneous use).
  • Negative interactions
    • ⓘ Concomitant use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.
    • ⓘ Tramadol and Codeine belong to the same pharmaceutical group: Opioid narcotic analgesics.
    • ⓘ Analeptics and psychostimulants reduce activity, completely block naloxone and naltrexone (direct antagonists).
    • ⓘ Inducers of microsomal oxidation (in pm carbamazepine, barbiturates) reduce the severity of the analgesic effect of tramadol and the duration of action.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine