Compatibility «Pentalginum-N» and «Montral ML»

• Interactions Pentalginum-N with Montral ML

  • Dangerous interactions
    • ⓘ Codeine (R05DA04) + H1-antihistamines; H2-antihistamines (R06, D04, R03BC) => Dangerous inhibition. (Avoid combined use).
    • ⓘ Respiratory analeptics (R07A_B) + h1 and h2-antihistamines => Convulsive syndrome may occur.
    • ⓘ H1-antihistamines; H2-antihistamines (R06, D04, R03BC) + Respiratory stimulants (R07AB, N06BC) => Combined use leads to the development of convulsive syndrome.
    • ⓘ Hypnotics, Barbiturates, glutetimide, nitrazepam, etc. + Antihistamines with a sedative component (diphedrol, diprazine, suprastin), antihypertensive agents (clofelin, reserpine), neuroleptics (aminazine, haloperidol), tranquilizers (sibazone) => Increased hypnotic effect up to toxic.
  • Negative interactions
    • ⓘ The AUC value decreases with simultaneous administration of phenobarbital (by about 40%), however, correction of the dosage regimen of montelukast is not required.
    • ⓘ Since montelukast is metabolized by the isoenzyme SUR3A4, caution should be exercised if montelukast is simultaneously prescribed with drugs that induce the isoenzyme SUR3A4, such as phenytoin, phenobarbital and rifampicin.
    • ⓘ Phenobarbital, which induces metabolism in the liver, reduced the AUC of montelukast by about 40% after a single dose of montelukast at a dose of 10 mg, dose adjustment of montelukast is not recommended.
  • Unclear interactions
    • ⓘ These drugs included thyroid hormones, sedative hypnotics, NSAIDs, benzodiazepines and decongestants.
    • ⓘ Montelukast.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine