Compatibility «Pentalgin» and «Coldact Flu Plus»

• Interactions Pentalgin with Coldact Flu Plus

  • Dangerous interactions
    • ⓘ Respiratory analeptics (R07A_B) + h1 and h2-antihistamines => Convulsive syndrome may occur.
    • ⓘ H1-antihistamines; H2-antihistamines (R06, D04, R03BC) + Respiratory stimulants (R07AB, N06BC) => Combined use leads to the development of convulsive syndrome.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
  • Negative interactions
    • ⓘ Drugs: Pentalgin and Coldact Flu Plus there is common active substance : Paracetamol. Pay attention to the dosage..
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Paracetamol and Naproxen belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ The clinical significance of this interaction is unknown, however, as with other NSAIDs, the simultaneous use of naproxen and acetylsalicylic acid is usually not recommended due to the potential increase in side effects.
    • ⓘ Pheniramine and Chlorphenamine belong to the same pharmaceutical group: H1-antihistamines.
  • Unclear interactions
    • ⓘ Caffeine + Phenylephrine analgin and citramon are used together in 20 preparations.
    • ⓘ Chlorphenamine + Caffeine analgin and citramon are used together in 17 preparations.
    • ⓘ Paracetamol+Phenylephrine+Chlorphenamine + Paracetamol analgin and citramon are used together in Antiflu, TeraFlu ExtraTab, Coldact Flu Plus.
    • ⓘ Paracetamol + Phenylephrine analgin and citramon are used together in 79 preparations.
    • ⓘ Paracetamol + Chlorphenamine analgin and citramon are used together in 34 preparations.
    • ⓘ Paracetamol + Drotaverine+Caffeine+Naproxen+Paracetamol+Pheniramine analgin and citramon are used together in Pentalgin, СПАЗМАЛГОН ЭФФЕКТ.
    • ⓘ Drotaverine + Paracetamol analgin and citramon are used together in 6 preparations.
    • ⓘ Paracetamol + Caffeine analgin and citramon are used together in 88 preparations.
    • ⓘ Paracetamol + Naproxen analgin and citramon are used together in Pentalgin, СПАЗМАЛГОН ЭФФЕКТ, Pentalgin NEO.
    • ⓘ Pheniramine + Paracetamol analgin and citramon are used together in 37 preparations.
    • ⓘ Pheniramine + Phenylephrine analgin and citramon are used together in 24 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine