Compatibility «Xarelto» and «Pentalginum-N»

• Interactions Xarelto with Pentalginum-N

  • Dangerous interactions
    • ⓘ The simultaneous use of enoxaparin sodium, warfarin, acetylsalicylic acid, clopidogrel and the constant use of NSAIDs may increase the risk of bleeding.
    • ⓘ NSAIDs are known to increase the risk of bleeding and this risk may increase with the simultaneous use of NSAIDs with rivaroxaban.
    • ⓘ Caution should be exercised when using Xarelto in combination with NSAIDs (including acetylsalicylic acid) and antiplatelet agents, since the use of these drugs usually increases the risk of bleeding.
    • ⓘ The simultaneous use of rivaroxaban with other powerful inducers of CYP3A4 (in pm phenytoin, carbamazepine, phenobarbital or St. John's wort) may also lead to a decrease in the concentration of rivaroxaban in plasma.
  • Negative interactions
    • ⓘ Any signs or symptoms of blood loss should be evaluated immediately if patients are simultaneously receiving acetylsalicylic acid, other platelet aggregation inhibitors, or NSAIDs (see 'Precautions').
    • ⓘ After simultaneous administration of Xarelto (15 mg) and naproxen (500 mg), there was no clinically significant increase in bleeding time.
    • ⓘ Enhances the metabolism of drugs biotransforming in the liver (due to the activation of microsomal oxidation enzymes) and reduces the effect of: indirect anticoagulants, PM warfarin, acenocumarol, phenindione, etc; (lowers the level of anticoagulants in the blood, with simultaneous administration, periodic monitoring of PV is necessary to correct doses of anticoagulants), corticosteroids, digitalis preparations, chloramphenicol, metronidazole, doxycycline (reduces T _1/2 doxycycline, this effect can persist for 2 weeks after discontinuation of barbiturate), tricyclic antidepressants, estrogens, salicylates, paracetamol, etc.; Phenobarbital reduces the absorption of griseofulvin and its level in the blood.
  • No interactions
    • ⓘ Neither naproxen nor acetylsalicylic acid affected the pharmacokinetics of rivaroxaban.
    • ⓘ Simultaneous administration of omeprazole proton pump inhibitor, H₂-histamine receptor antagonist ranitidine, aluminum hydroxide/magnesium hydroxide antacid, naproxen, clopidogrel or enoxaparin has no effect on the bioavailability and pharmacokinetics of rivaroxaban.
  • Unclear interactions
    • ⓘ Anticoagulants and NSAIDs/acetylsalicylic acid.
    • ⓘ NSAIDs/acetylsalicylic acid.
    • ⓘ Anticoagulants.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine