Description Source
Encyclopedia of Pure Materia Medica - TF AllenAdditional facts
Sulphate of quinine or chinin. Formula 2C20 H24 N2 O2, SH2 O4 plus 7H2 O (Regnault). Preparation: for use, Triturations.
Mental
Mind. Emotional.
Excited. Sensation as though he were intoxicated though his mental powers were perfect. An intoxicated sensation, changing to a heaviness of the head (5th day). Uncommonly lively mood (9th day). An extremely lively mood and an activity returned about 9 only after a walk in the open air (8th day).
Buoyant feeling in the evening (12th day). Rather more vim and buoyancy than usual, during the evening especially (2nd day). Feeling of considerable mental resolution, with shrinking from taking much trouble about matters, evening (26th day). Found my will positive in insisting on professional orders, but self-restrained and deliberate, in the forenoon (17th day). Awoke at midnight with long continued cries; he knew that he was crying, but could not help it; he was obliged to get out of bed; he wrapped himself in the clothes, and remained sitting; after a few minutes he came to himself again, and soon felt asleep (6th day). Great depression of spirits (14th day). Great depression of spirits and fretfulness (11th day). Despondency. During much of the proving the morale has been one of will, with little courage, or hope, or contentment, which, however, I am not prepared to attribute to the drug with confidence (27th day). Anxiety (after 2 hours).
Great anxiety, amounting to an apprehension, as if some evil would happen (5th day). Attacks of anxiety (3rd day). Feeling of anxiety, which at times obliges him to leave the bed (3rd and 4th nights). Anxious and sleepless during the night. The day being clear and windy, and a holiday to many, few people being on the street produced a sort of street-quietness; felt a gloom come over me, сas if some evil were impending; relieved by a specific trust in the Almighty; this from 3 to 4.15 (1st day). Recurrence of feeling of impending evil, in the afternoon (6th day). Ill-humored and fretful (9th day). After sleep, readily angered, even by a cold draft on my legs (40th day).
Intellectual. The morale, from the first, has resembled the physical symptoms, dull feelings in both coexisting; in both simultaneously sharpness, the former in the beginning, the latter at present (20th day). Thought difficult, while writing (5th day). Great disinclination to mental labor (8th day). Averse to difficult study or other work (12th day). At 12 , some repugnance to the prospective burden of tomorrow’s business (having partaken of vegetable soup, an orange taken after that); then at 12.25 took another powder; then, leaning over my table, tasted the food (2nd day). 4.30 , whilst writing, was interrupted; decided feeling to cut it short (1st day). Wrote right instead of left by mistake (28th day). Wrote the word left instead of right afternoon (26th day). Wrote the word left instead of right; have made a number of similar mistakes in talking during the past few days, in the evening (14th day).
Again I mistakenly wrote at first left instead of right (I remember a report I published some time ago of contusion of the spine cured by Hypericum, in which the same error occurs; I do not remember whether I had then taken any medicine; possibly I had taken сhina or some other), (15th day). Memory all muddled . Lost the power of naming substantives; was obliged for a long while to consider what different familiar things were called; and as to casting up a line of six or eight figures correctly, it was utterly impossible; he could never make the amount twice alike; his perceptions of quantity were greatly impaired, so that in prescriptions he wrote ounces instead of drachms, ordered drachms instead of grains, directed draughts to be put in gallipots, and prescribed fluids to be made into pills (14 to 16 grains daily).
Excited. Sensation as though he were intoxicated though his mental powers were perfect. An intoxicated sensation, changing to a heaviness of the head (5th day). Uncommonly lively mood (9th day). An extremely lively mood and an activity returned about 9 only after a walk in the open air (8th day).
Buoyant feeling in the evening (12th day). Rather more vim and buoyancy than usual, during the evening especially (2nd day). Feeling of considerable mental resolution, with shrinking from taking much trouble about matters, evening (26th day). Found my will positive in insisting on professional orders, but self-restrained and deliberate, in the forenoon (17th day). Awoke at midnight with long continued cries; he knew that he was crying, but could not help it; he was obliged to get out of bed; he wrapped himself in the clothes, and remained sitting; after a few minutes he came to himself again, and soon felt asleep (6th day). Great depression of spirits (14th day). Great depression of spirits and fretfulness (11th day). Despondency. During much of the proving the morale has been one of will, with little courage, or hope, or contentment, which, however, I am not prepared to attribute to the drug with confidence (27th day). Anxiety (after 2 hours).
Great anxiety, amounting to an apprehension, as if some evil would happen (5th day). Attacks of anxiety (3rd day). Feeling of anxiety, which at times obliges him to leave the bed (3rd and 4th nights). Anxious and sleepless during the night. The day being clear and windy, and a holiday to many, few people being on the street produced a sort of street-quietness; felt a gloom come over me, сas if some evil were impending; relieved by a specific trust in the Almighty; this from 3 to 4.15 (1st day). Recurrence of feeling of impending evil, in the afternoon (6th day). Ill-humored and fretful (9th day). After sleep, readily angered, even by a cold draft on my legs (40th day).
Intellectual. The morale, from the first, has resembled the physical symptoms, dull feelings in both coexisting; in both simultaneously sharpness, the former in the beginning, the latter at present (20th day). Thought difficult, while writing (5th day). Great disinclination to mental labor (8th day). Averse to difficult study or other work (12th day). At 12 , some repugnance to the prospective burden of tomorrow’s business (having partaken of vegetable soup, an orange taken after that); then at 12.25 took another powder; then, leaning over my table, tasted the food (2nd day). 4.30 , whilst writing, was interrupted; decided feeling to cut it short (1st day). Wrote right instead of left by mistake (28th day). Wrote the word left instead of right afternoon (26th day). Wrote the word left instead of right; have made a number of similar mistakes in talking during the past few days, in the evening (14th day).
Again I mistakenly wrote at first left instead of right (I remember a report I published some time ago of contusion of the spine cured by Hypericum, in which the same error occurs; I do not remember whether I had then taken any medicine; possibly I had taken сhina or some other), (15th day). Memory all muddled . Lost the power of naming substantives; was obliged for a long while to consider what different familiar things were called; and as to casting up a line of six or eight figures correctly, it was utterly impossible; he could never make the amount twice alike; his perceptions of quantity were greatly impaired, so that in prescriptions he wrote ounces instead of drachms, ordered drachms instead of grains, directed draughts to be put in gallipots, and prescribed fluids to be made into pills (14 to 16 grains daily).
Head, face, and ears
Head. - сonfusion and Vertigo.
Confusion of the head (5th and 20th days). Vertigo; (after one hour and a quarter). Vertigo, on stooping (21st day).
Vertigo and whirling in the head (29th day). Vertigo and palpitation (after 4 hours). Whirling in the head, like a mill wheel (31st day). General Head. In morning, whole head swollen, and the face so altered that she could with great difficulty open her mouth for food. Rush of blood to the head. Rush of blood to the head, towards evening.
Chronic disturbance of brain. Head stupefied, and especially painful in the left temple (26th day). Head empty, in the morning. Light, hollow feeling in head. Heaviness in the head (7th day). Heaviness and confusion of the head continue until going to sleep in the evening (7th day). Heavy feeling in head, especially the top, in the evening (27th day). Heavy felling in the head is notable; sitting after stool with protrusion; the room being somewhat warm, the day stormy. It is not unlike the inertia of the muscles of the legs in walking before mentioned; it is also attended by a sense of vascular tension and fullness and dry heat, fingers and feet cold; the head feels much better by application of my cold hand on the top, in the forenoon (28th day). Pain in the head (after one hour). Very violent pain in the head, on rising in the morning, especially noticed on stooping or moving (29th day). Such fullness in the head that he was unable to walk. Sudden fullness of head (head leaning to left), especially the left side and top, after writing, in the forenoon (28th day). Head feels full while sitting writing, in forenoon (28th day). A moderate excitement caused a marked feeling of dull tension (not a rare symptom) about the head, especially at the sides; settling on the top as a pressure, extending later to the perceptive region on the forehead, at last completing the circuit to occiput like a rim, in the morning (23rd day).
Headache. (10th day). Headache (boy, after 25 minutes, lasted 5 minutes); (girl, from 8 grains, began in 170 minutes; from 10 grains, in 175 minutes; from 12 grains, in 95 minutes; from 20 grains, in 30 minutes; from 20 grains, in 15 minutes). Headache, extending to the temples, in the afternoon, and was somewhat relieved towards evening (18th day). Headache after walking a long time in the sun, in the afternoon (7th day). Headache at 3 p.m, with violent pressive pains in the occiput, which only disappear on rising (2nd day). Headache at 7 , commencing in the forehead, and at last extending to the occiput, lasting an hour (13th day). Headache, with vertigo and loss of consciousness. Very severe headache, worse towards evening, with violent palpitation of the arteries of the head, as if the head would be torn as under, with glowing heat of the face, vertigo, at times ringing and roaring in the ears. Violent headache, which disappeared after 8 to 12 days. Violent headache in the forenoon, more especially in the left side, with frequent pulsation of the temporal arteries, with excitement through the whole body (12th day). Dull headache (14th day). The headache and fever were relieved on walking in the open air, with appearance of slight sweat (31st day). I rose and bent over my table; then throbbing in the head and shoulders; forgot it on going out (1st day).
Forehead. About 4 , the frontal arteries began to pulsate, the heat of the face increased to redness, and continued; especially was it the most intense about the eyes (7th day). Pain in the forehead, (22nd day). Pain in the forehead after dinner (7th day). Pain in the forehead between 5 and 6 (3rd and 4th days). Pain in the forehead and temples appeared towards evening, and gradually increased in intensity, with visible pulsation of the temporal arteries, heat of the head, and ringing in the ears (4th day). Some pain in the forehead in the afternoon (5th day). Some pain in the forehead about 4 (2nd day). Much pain in the forehead and temples (8th day). Violent pain in the forehead, lasting 24 hours (after 4 hours). Violent pain in the forehead two hours after 2 grains it disappeared in the course of the afternoon (5th day). Extremely violent pain in the left side of the forehead; with vertigo, ringing in the ear, and weakness as from long illness, at 9 p.m (18th day). Frontal headache from 1 to 4 (31st day). Slight frontal headache, lasting a;; day, and becoming worse towards evening. Violent frontal headache on waking (23rd day). Violent frontal headache in the evening (5th day). Severe frontal headache, worse on the left side on rising in the morning, becoming somewhat less during the forenoon, but succeeded by confusion of the head the whole day; it was again worse at 5 without any general excitement (19th day). Dull frontal headache (24th day ). Headache in the forehead and left temple (13th day). Dull headache, extending from the temples to the middle of the forehead, in the afternoon (8th day). Drawing headache extending from the temples of the middle of the forehead (27th day). Pressive pain in the forehead and orbits, aggravated by moving the eyes or turning the head. Sudden boring sticking in the left center of the forehead; spot like the end of the little finger, in the evening (23rd day).
Temples. Temporal arteries and veins of hands seem quite full, evening (26th day). Repeated twitching of fibres of temporal muscles above left zygoma, in the afternoon (24th day). Violent pains in the left temple. pain extends to the eyebrow, and obliges him to lie down with which he seeks a cool, place on the sofa in order to relieve the pain (1st day).
Violent headache in the temples towards evening (29th day). Dull pressing pain in the temples (27th day). (100. Sitting at table, leaned to right, neuralgic sensation shot up the anterior left temple (42nd day). Vertex. Reading bent forward, steady neuralgic pain from the right supraorbital foramen, straight up, to vertex, in a narrow, line, ceased after sitting up straight in the night (20th day). Parietals.
Dull neuralgia, left parietal region, then right vertex, in the evening (24th day). On raising the eyebrow, neuralgic pain from outer right brow up that side of the head; then a slight twinge in outer end of;left eyebrow, early in morning (19th day).
Left side of head and throat feel as if they would ache (not rare). in the afternoon (3rd day). Whilst writing, with head inclined to left, dull headache on the right side (after 5 minutes). I Have the like sometimes from constipation or from mechanical tension of the right cervical muscles (12th day).
Whilst writing dull ache right side extending as a sharp neuralgic sensation to right outer brow, and dull later, to right mastoid process, returning slightly to brow, and up temporal ridge, same side, again in ear, right side, then back to brow later, a catch in middle of right sternomastoid muscle, when turning head that way, after midnight (17th day). Whilst writing, with head inclined to left side, dull headache on left side (similar to early symptoms), extends to left side to neck and throat, and right mastoid process, then to vertex, then to occiput; shifting, then to brows (varying with position of head), now pressing in both temples, extending over coronal suture, in the morning (21st day). Slight dull headache, right side (old symptom since an attack of fever, with misapplied water-cure, in 1860, in Illinois), in the afternoon (14th day). Whilst standing holding my head down, a little dull stitch in upper left parietal, felt also to root of nose, left side (soon), (15th day). On suddenly rising to a standing posture, a quick stitch in left upper parietal region (soon), (14th day). Walking in open air, neuralgic twinge, right side of head, lingering some time in upper right temple, in the evening (18th day). Sitting, sudden neuralgic twinge in right side of head, from brow to lambdoidal suture, in the evening (18th day). When about to dine, and whilst standing, return of the twinge from outer right brow to lambdoidal suture i. e., above temporal ridge (19th day). On going out with head down, sharp neuralgic twinge in and behind left parietal protuberance, in the afternoon (20th day).
Occiput. Threatening of dull headache, left occiput, in the evening (19th day). Dull twinges, left occipital protuberance, becoming a steady ache for a short time, in the afternoon (24th day). On holding up head suddenly to right, a little shock across lower occiput, in the evening (15th day).
External Head. Dandruff in large amount also falls when scratching the scalp, attended by relief; also similar conditions in the beard on the chin, especially left side, in the evening (24th day). Prickling in the forehead, with confusion of the same (7th day). Recurrence of itching of scalp here and there, coming and going, in the evening (24th day). Whilst writing, itching above edge of frontal hair, right and left sides, then below right zygoma, then right side of top of head, then left vertex, right chin, left post- mastoid surface, inner left eyebrow, etc. (21st day). Itching in vertex and occiput, left side (21st day).
Eye. Objective.
Lusterless eyes. Gray rings about the eyes (26th day).
With some, the eyes become red and there is swelling of the lids, with the appearance of pimples. Eyes restless (12th day).
Subjective. Peculiar dryness of the eyes. All day, eyes feel as if they had been in a flare, or as if the atmosphere were too dry, as if parched (20th day). Walking in the wind I observed the cessation of the parched feeling in the eyes, and in the right lachrymation in the evening (20th day). Eyes and frontal region feel heavy, in the afternoon (3rd day). While sitting, sleepy feeling in the eyes, in the afternoon (16th day). вrow and Orbit. From the beginning of proving, have had an habitual symptom considerably increased, i. e., disposition to contract eyebrows). Slight neuralgic sensation, right inner brow, when bending forward in the morning (20th day). Dull neuralgic grip, in outer right brow, deep seated; then, a somewhat similar pain in (outer) left biceps tendon, whilst holding the forearm flexed and pronated, hand on edge of table, at noon (24th day). Recurrence of neuralgic ache, outer half of right brow, after midnight (24th day). Whilst writing, stitch at inner left eyebrow, in the evening (14th day). Twinges about right outer brow, and various other places, in the afternoon (19th day). Neuralgic twinge in outer right brow, at 11.30 (18th day). Neuralgic twinge, inner right eyebrow (18th day). Neuralgic twinges, alternating in both brows; rather dull in character, in the night (21st day). While sitting, hard aching in outer half of orbit, above it, below it, and in the eyeball (I think this was on the right side), in the evening (23rd day). Pain in left infra- orbital nerve (slight ache), in the night at 1.30 p.m (26th day). Pain in left infra-orbital, malar, and superior maxillary nerves; aching and boring, worse in cold air, but nearly constant even involving the eye at times, with tumefaction adjacent to upper molars (40th day). Slight pain recurring in right outer supraorbital region, in the early morning (26th day).
Neuralgic pain in right supraorbital nerve, then in left (whilst sitting in street car), in the evening (25th day). Whilst writing, neuralgic pain in left supraorbital nerve, slight, near foramen, in the evening (18th day). Neuralgic twinge in left supraorbital nerve, in the forenoon (19th day). Sitting in church, felt a neuralgic twinge in right supraorbital nerve, near foramen (19th day). Flashing in branches of infra-orbital nerve, left side, in the afternoon (20th day). Lids. Eyes closed from weakness, while writing (5th day). Twitching of left eyelid (recurrence), several previous occasions not noted (23rd day). Twitching of left eyelids; outer canthus, as most commonly (13th day). Twitching of left eyelids, in the evening (25th day). Whilst writing, renewed twitching in left eyelids, evening (26th day). Decided twitching of left eyelid, in the afternoon (25th day). Repeated twitchings in left eyelids, especially the lower, afternoon (26th day).
Lachrymal Apparatus. Lachrymation in the open air (29th day). On going out (air not very cold, but sunshiny), lachrymation from both eyes, obscuring sight. Not rare in right eye; but now, worse in left) (5th day). Lachrymation of the eyes in the full light, at 5 (7th day).
Conjunctiva. Dirty color to the white of the eyes.
Ball. Disk on both sides, now decidedly paler (10 gr. doses), (after 2 and a half hours). Disk and retina both very anemic. Disk looks dry, with the vessels smaller than usual running over it (10 gr. doses), (after one and a half hours).
Vessels on the disk appear smaller, and the disk itself of a papery whiteness (10 gr. doses), (after one and a half hours).
With five grain doses, the effects on one observer were similar to those already mentioned, though not so marked; with the other observer, on one occasion, when the quinine created considerable disturbance of the stomach, a diminution of the vascularity was observed only to a slight extent, and about an hour and a half after exhibition of the dose; otherwise, the fundus remained, as it had been at the first, rather congested.
Pupil. Dimness of the pupils. Pupils dilated.
Pupils much dilated,; (after eight hours). Mydriasis.
Vision. Dim vision. Dimness of vision, as from a net before the eyes, and once, as from a dark fog. Dimness of sight (girl, 5, from 10 grs). of left eye only, began in 177 min., lasting 40 min.; from 8 grs., first of left eye, then of right, in the latter continuing after it had disappeared from the former; from 20 grs., appeared in 20 min., first in right, then in left eye, lasted 160 min.; from 20 grs., appeared in 25 min., in right eye only, lasted 105 min.
Amaurosis (2 cases). More or less complete, or even incurable amaurosis of one or both eyes. Sight and hearing nearly lost. Sight lost (after 8 hours). вlindness. Great sensitiveness of the eye to the light, with lachrymation in the full glare of light (13th day). Sitting at a lecture, the glare of light felt disagreeable, although it is a dull day; drowsy, had to shut my eyes and press the inner canthi, in the afternoon (27th day). Sparks before eyes when sunlight is strong, for one week (after 4 weeks). вright lights and sparks before the eyes. вlack spot, size of pin’s head, about 18 inches from right eye, and moving with eye for some weeks (after 18 days). вlackness before the eyes, with pain in the forehead, so violent that the head seemed as though it would burst (31st day).
Ear. External.
From entrance of cool wind, left ear and neck instantly felt rheumatic, i. e., neck extending towards ear (29th day). Aching above right mastoid process and ear, in the evening (21st day).
Parotid tension and flow (29th day). Sitting, tension in parotids recurs, with flow of saliva, in the afternoon (24th day). After supper, walking, after a little jar, sudden tension in right parotid region, with flow of saliva (28th day). At 11.30 , tension set in, and flow of saliva from right parotid gland, also right submaxillary; afterwards the left glands likewise. сontinued up to time of taking second powder, and falling asleep, 12 (1st day). Internal. Pain in right ear, then below left zygoma, between 1 and 2 p.m (26th day). Sudden aching in left ear, while walking out of doors, in the afternoon (14th day). Sticking in right ear at noon (20th day). Sticking in left ear, involving the throat then drawing in the chin (23rd day). Left side, sticking, slow and dull in the ear in the forenoon (24th day). After going downstairs, sticking in left meatus auditorius, very slight, but recurrent, in the after noon (15th day). Hearing.
Difficult hearing, on 2nd or 3rd day. Hearing lost (after 8 hours). Deafness of both ears on account of loud ringing in them (31st day). Transient deafness in the left ear (twenty six day) The child became completely deaf for several years and never quite recovered. Morning in bed, the not heavy tread of another person in the room is intolerable; it seems to go through my head (47th day). Intolerant of the noise of boys behind me in the street whilst walking home, crossed the street to be rid of them, but the church music had been very enjoyable, evening (26th day). Slight and transient resonance in right ear, in the morning (20th day). The characteristic tingling in the ears, was felt with the ten grain doses. Ringing in he ears (after 4 hour).
Ringing in the ears, especially noticed in the left, seldom in the right (26th day). Ringing in the ears, with frequent interruptions (19th and 20th days). Ringing in ear, with sensation as if they were filled or plugged up. Frequent transient ringing in the ears. сonstant ringing in the ear (1st day). сonstant ringing, hissing. sound in ears. Noises in the ears, buzzing sound, as if bells were ringing (boys, after 35 m, minutes, lasting about 5 minutes); (girl, from 8 grains, began in one hundred and ten minutes, and lasted 80 minutes; from 12 grains, began in 15 minutes; from 20 grains began in 40 minutes). Walked out, whilst doing so, sudden transient sounding in right ear, like the tone of the bell in E. (18th day). Roaring in the ears. Roaring in the ears and head. Roaring in the ears, so that the patient was almost completely deaf. Roaring in the ears, with transient deafness. сonstant roaring in the ears. сonstant roaring in he ears, for several years. Great roaring in the ears. (after 45 minutes).
Confusion of the head (5th and 20th days). Vertigo; (after one hour and a quarter). Vertigo, on stooping (21st day).
Vertigo and whirling in the head (29th day). Vertigo and palpitation (after 4 hours). Whirling in the head, like a mill wheel (31st day). General Head. In morning, whole head swollen, and the face so altered that she could with great difficulty open her mouth for food. Rush of blood to the head. Rush of blood to the head, towards evening.
Chronic disturbance of brain. Head stupefied, and especially painful in the left temple (26th day). Head empty, in the morning. Light, hollow feeling in head. Heaviness in the head (7th day). Heaviness and confusion of the head continue until going to sleep in the evening (7th day). Heavy feeling in head, especially the top, in the evening (27th day). Heavy felling in the head is notable; sitting after stool with protrusion; the room being somewhat warm, the day stormy. It is not unlike the inertia of the muscles of the legs in walking before mentioned; it is also attended by a sense of vascular tension and fullness and dry heat, fingers and feet cold; the head feels much better by application of my cold hand on the top, in the forenoon (28th day). Pain in the head (after one hour). Very violent pain in the head, on rising in the morning, especially noticed on stooping or moving (29th day). Such fullness in the head that he was unable to walk. Sudden fullness of head (head leaning to left), especially the left side and top, after writing, in the forenoon (28th day). Head feels full while sitting writing, in forenoon (28th day). A moderate excitement caused a marked feeling of dull tension (not a rare symptom) about the head, especially at the sides; settling on the top as a pressure, extending later to the perceptive region on the forehead, at last completing the circuit to occiput like a rim, in the morning (23rd day).
Headache. (10th day). Headache (boy, after 25 minutes, lasted 5 minutes); (girl, from 8 grains, began in 170 minutes; from 10 grains, in 175 minutes; from 12 grains, in 95 minutes; from 20 grains, in 30 minutes; from 20 grains, in 15 minutes). Headache, extending to the temples, in the afternoon, and was somewhat relieved towards evening (18th day). Headache after walking a long time in the sun, in the afternoon (7th day). Headache at 3 p.m, with violent pressive pains in the occiput, which only disappear on rising (2nd day). Headache at 7 , commencing in the forehead, and at last extending to the occiput, lasting an hour (13th day). Headache, with vertigo and loss of consciousness. Very severe headache, worse towards evening, with violent palpitation of the arteries of the head, as if the head would be torn as under, with glowing heat of the face, vertigo, at times ringing and roaring in the ears. Violent headache, which disappeared after 8 to 12 days. Violent headache in the forenoon, more especially in the left side, with frequent pulsation of the temporal arteries, with excitement through the whole body (12th day). Dull headache (14th day). The headache and fever were relieved on walking in the open air, with appearance of slight sweat (31st day). I rose and bent over my table; then throbbing in the head and shoulders; forgot it on going out (1st day).
Forehead. About 4 , the frontal arteries began to pulsate, the heat of the face increased to redness, and continued; especially was it the most intense about the eyes (7th day). Pain in the forehead, (22nd day). Pain in the forehead after dinner (7th day). Pain in the forehead between 5 and 6 (3rd and 4th days). Pain in the forehead and temples appeared towards evening, and gradually increased in intensity, with visible pulsation of the temporal arteries, heat of the head, and ringing in the ears (4th day). Some pain in the forehead in the afternoon (5th day). Some pain in the forehead about 4 (2nd day). Much pain in the forehead and temples (8th day). Violent pain in the forehead, lasting 24 hours (after 4 hours). Violent pain in the forehead two hours after 2 grains it disappeared in the course of the afternoon (5th day). Extremely violent pain in the left side of the forehead; with vertigo, ringing in the ear, and weakness as from long illness, at 9 p.m (18th day). Frontal headache from 1 to 4 (31st day). Slight frontal headache, lasting a;; day, and becoming worse towards evening. Violent frontal headache on waking (23rd day). Violent frontal headache in the evening (5th day). Severe frontal headache, worse on the left side on rising in the morning, becoming somewhat less during the forenoon, but succeeded by confusion of the head the whole day; it was again worse at 5 without any general excitement (19th day). Dull frontal headache (24th day ). Headache in the forehead and left temple (13th day). Dull headache, extending from the temples to the middle of the forehead, in the afternoon (8th day). Drawing headache extending from the temples of the middle of the forehead (27th day). Pressive pain in the forehead and orbits, aggravated by moving the eyes or turning the head. Sudden boring sticking in the left center of the forehead; spot like the end of the little finger, in the evening (23rd day).
Temples. Temporal arteries and veins of hands seem quite full, evening (26th day). Repeated twitching of fibres of temporal muscles above left zygoma, in the afternoon (24th day). Violent pains in the left temple. pain extends to the eyebrow, and obliges him to lie down with which he seeks a cool, place on the sofa in order to relieve the pain (1st day).
Violent headache in the temples towards evening (29th day). Dull pressing pain in the temples (27th day). (100. Sitting at table, leaned to right, neuralgic sensation shot up the anterior left temple (42nd day). Vertex. Reading bent forward, steady neuralgic pain from the right supraorbital foramen, straight up, to vertex, in a narrow, line, ceased after sitting up straight in the night (20th day). Parietals.
Dull neuralgia, left parietal region, then right vertex, in the evening (24th day). On raising the eyebrow, neuralgic pain from outer right brow up that side of the head; then a slight twinge in outer end of;left eyebrow, early in morning (19th day).
Left side of head and throat feel as if they would ache (not rare). in the afternoon (3rd day). Whilst writing, with head inclined to left, dull headache on the right side (after 5 minutes). I Have the like sometimes from constipation or from mechanical tension of the right cervical muscles (12th day).
Whilst writing dull ache right side extending as a sharp neuralgic sensation to right outer brow, and dull later, to right mastoid process, returning slightly to brow, and up temporal ridge, same side, again in ear, right side, then back to brow later, a catch in middle of right sternomastoid muscle, when turning head that way, after midnight (17th day). Whilst writing, with head inclined to left side, dull headache on left side (similar to early symptoms), extends to left side to neck and throat, and right mastoid process, then to vertex, then to occiput; shifting, then to brows (varying with position of head), now pressing in both temples, extending over coronal suture, in the morning (21st day). Slight dull headache, right side (old symptom since an attack of fever, with misapplied water-cure, in 1860, in Illinois), in the afternoon (14th day). Whilst standing holding my head down, a little dull stitch in upper left parietal, felt also to root of nose, left side (soon), (15th day). On suddenly rising to a standing posture, a quick stitch in left upper parietal region (soon), (14th day). Walking in open air, neuralgic twinge, right side of head, lingering some time in upper right temple, in the evening (18th day). Sitting, sudden neuralgic twinge in right side of head, from brow to lambdoidal suture, in the evening (18th day). When about to dine, and whilst standing, return of the twinge from outer right brow to lambdoidal suture i. e., above temporal ridge (19th day). On going out with head down, sharp neuralgic twinge in and behind left parietal protuberance, in the afternoon (20th day).
Occiput. Threatening of dull headache, left occiput, in the evening (19th day). Dull twinges, left occipital protuberance, becoming a steady ache for a short time, in the afternoon (24th day). On holding up head suddenly to right, a little shock across lower occiput, in the evening (15th day).
External Head. Dandruff in large amount also falls when scratching the scalp, attended by relief; also similar conditions in the beard on the chin, especially left side, in the evening (24th day). Prickling in the forehead, with confusion of the same (7th day). Recurrence of itching of scalp here and there, coming and going, in the evening (24th day). Whilst writing, itching above edge of frontal hair, right and left sides, then below right zygoma, then right side of top of head, then left vertex, right chin, left post- mastoid surface, inner left eyebrow, etc. (21st day). Itching in vertex and occiput, left side (21st day).
Eye. Objective.
Lusterless eyes. Gray rings about the eyes (26th day).
With some, the eyes become red and there is swelling of the lids, with the appearance of pimples. Eyes restless (12th day).
Subjective. Peculiar dryness of the eyes. All day, eyes feel as if they had been in a flare, or as if the atmosphere were too dry, as if parched (20th day). Walking in the wind I observed the cessation of the parched feeling in the eyes, and in the right lachrymation in the evening (20th day). Eyes and frontal region feel heavy, in the afternoon (3rd day). While sitting, sleepy feeling in the eyes, in the afternoon (16th day). вrow and Orbit. From the beginning of proving, have had an habitual symptom considerably increased, i. e., disposition to contract eyebrows). Slight neuralgic sensation, right inner brow, when bending forward in the morning (20th day). Dull neuralgic grip, in outer right brow, deep seated; then, a somewhat similar pain in (outer) left biceps tendon, whilst holding the forearm flexed and pronated, hand on edge of table, at noon (24th day). Recurrence of neuralgic ache, outer half of right brow, after midnight (24th day). Whilst writing, stitch at inner left eyebrow, in the evening (14th day). Twinges about right outer brow, and various other places, in the afternoon (19th day). Neuralgic twinge in outer right brow, at 11.30 (18th day). Neuralgic twinge, inner right eyebrow (18th day). Neuralgic twinges, alternating in both brows; rather dull in character, in the night (21st day). While sitting, hard aching in outer half of orbit, above it, below it, and in the eyeball (I think this was on the right side), in the evening (23rd day). Pain in left infra- orbital nerve (slight ache), in the night at 1.30 p.m (26th day). Pain in left infra-orbital, malar, and superior maxillary nerves; aching and boring, worse in cold air, but nearly constant even involving the eye at times, with tumefaction adjacent to upper molars (40th day). Slight pain recurring in right outer supraorbital region, in the early morning (26th day).
Neuralgic pain in right supraorbital nerve, then in left (whilst sitting in street car), in the evening (25th day). Whilst writing, neuralgic pain in left supraorbital nerve, slight, near foramen, in the evening (18th day). Neuralgic twinge in left supraorbital nerve, in the forenoon (19th day). Sitting in church, felt a neuralgic twinge in right supraorbital nerve, near foramen (19th day). Flashing in branches of infra-orbital nerve, left side, in the afternoon (20th day). Lids. Eyes closed from weakness, while writing (5th day). Twitching of left eyelid (recurrence), several previous occasions not noted (23rd day). Twitching of left eyelids; outer canthus, as most commonly (13th day). Twitching of left eyelids, in the evening (25th day). Whilst writing, renewed twitching in left eyelids, evening (26th day). Decided twitching of left eyelid, in the afternoon (25th day). Repeated twitchings in left eyelids, especially the lower, afternoon (26th day).
Lachrymal Apparatus. Lachrymation in the open air (29th day). On going out (air not very cold, but sunshiny), lachrymation from both eyes, obscuring sight. Not rare in right eye; but now, worse in left) (5th day). Lachrymation of the eyes in the full light, at 5 (7th day).
Conjunctiva. Dirty color to the white of the eyes.
Ball. Disk on both sides, now decidedly paler (10 gr. doses), (after 2 and a half hours). Disk and retina both very anemic. Disk looks dry, with the vessels smaller than usual running over it (10 gr. doses), (after one and a half hours).
Vessels on the disk appear smaller, and the disk itself of a papery whiteness (10 gr. doses), (after one and a half hours).
With five grain doses, the effects on one observer were similar to those already mentioned, though not so marked; with the other observer, on one occasion, when the quinine created considerable disturbance of the stomach, a diminution of the vascularity was observed only to a slight extent, and about an hour and a half after exhibition of the dose; otherwise, the fundus remained, as it had been at the first, rather congested.
Pupil. Dimness of the pupils. Pupils dilated.
Pupils much dilated,; (after eight hours). Mydriasis.
Vision. Dim vision. Dimness of vision, as from a net before the eyes, and once, as from a dark fog. Dimness of sight (girl, 5, from 10 grs). of left eye only, began in 177 min., lasting 40 min.; from 8 grs., first of left eye, then of right, in the latter continuing after it had disappeared from the former; from 20 grs., appeared in 20 min., first in right, then in left eye, lasted 160 min.; from 20 grs., appeared in 25 min., in right eye only, lasted 105 min.
Amaurosis (2 cases). More or less complete, or even incurable amaurosis of one or both eyes. Sight and hearing nearly lost. Sight lost (after 8 hours). вlindness. Great sensitiveness of the eye to the light, with lachrymation in the full glare of light (13th day). Sitting at a lecture, the glare of light felt disagreeable, although it is a dull day; drowsy, had to shut my eyes and press the inner canthi, in the afternoon (27th day). Sparks before eyes when sunlight is strong, for one week (after 4 weeks). вright lights and sparks before the eyes. вlack spot, size of pin’s head, about 18 inches from right eye, and moving with eye for some weeks (after 18 days). вlackness before the eyes, with pain in the forehead, so violent that the head seemed as though it would burst (31st day).
Ear. External.
From entrance of cool wind, left ear and neck instantly felt rheumatic, i. e., neck extending towards ear (29th day). Aching above right mastoid process and ear, in the evening (21st day).
Parotid tension and flow (29th day). Sitting, tension in parotids recurs, with flow of saliva, in the afternoon (24th day). After supper, walking, after a little jar, sudden tension in right parotid region, with flow of saliva (28th day). At 11.30 , tension set in, and flow of saliva from right parotid gland, also right submaxillary; afterwards the left glands likewise. сontinued up to time of taking second powder, and falling asleep, 12 (1st day). Internal. Pain in right ear, then below left zygoma, between 1 and 2 p.m (26th day). Sudden aching in left ear, while walking out of doors, in the afternoon (14th day). Sticking in right ear at noon (20th day). Sticking in left ear, involving the throat then drawing in the chin (23rd day). Left side, sticking, slow and dull in the ear in the forenoon (24th day). After going downstairs, sticking in left meatus auditorius, very slight, but recurrent, in the after noon (15th day). Hearing.
Difficult hearing, on 2nd or 3rd day. Hearing lost (after 8 hours). Deafness of both ears on account of loud ringing in them (31st day). Transient deafness in the left ear (twenty six day) The child became completely deaf for several years and never quite recovered. Morning in bed, the not heavy tread of another person in the room is intolerable; it seems to go through my head (47th day). Intolerant of the noise of boys behind me in the street whilst walking home, crossed the street to be rid of them, but the church music had been very enjoyable, evening (26th day). Slight and transient resonance in right ear, in the morning (20th day). The characteristic tingling in the ears, was felt with the ten grain doses. Ringing in he ears (after 4 hour).
Ringing in the ears, especially noticed in the left, seldom in the right (26th day). Ringing in the ears, with frequent interruptions (19th and 20th days). Ringing in ear, with sensation as if they were filled or plugged up. Frequent transient ringing in the ears. сonstant ringing in the ear (1st day). сonstant ringing, hissing. sound in ears. Noises in the ears, buzzing sound, as if bells were ringing (boys, after 35 m, minutes, lasting about 5 minutes); (girl, from 8 grains, began in one hundred and ten minutes, and lasted 80 minutes; from 12 grains, began in 15 minutes; from 20 grains began in 40 minutes). Walked out, whilst doing so, sudden transient sounding in right ear, like the tone of the bell in E. (18th day). Roaring in the ears. Roaring in the ears and head. Roaring in the ears, so that the patient was almost completely deaf. Roaring in the ears, with transient deafness. сonstant roaring in the ears. сonstant roaring in he ears, for several years. Great roaring in the ears. (after 45 minutes).
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