Compatibility «Telmisartan» and «Acetylsalicylic acid+Caffeine+Paracetamol»

• Interactions Telmisartan with Acetylsalicylic acid+Caffeine+Paracetamol

  • Dangerous interactions
    • ⓘ In elderly people with reduced BCC (including those receiving diuretic therapy) or with impaired renal function, the combined use of NSAIDs, in pm, selective COX-2 inhibitors with ARA II, including telmisartan, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ The combined use of telmisartan did not lead to a clinically significant interaction with paracetamol, amlodipine, glibenclamide, simvastatin, hydrochlorothiazide, warfarin or ibuprofen.
  • Negative interactions
    • ⓘ Kidney function should be monitored periodically in patients receiving telmisartan and NSAIDs.
    • ⓘ The antihypertensive effect of ARA II, including telmisartan, can be weakened by NSAIDs, including selective COX-2 inhibitors.
    • ⓘ The risk may increase when combined with other medications that can also provoke hyperkalemia (salt substitutes containing potassium, potassium‑sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, nonsteroidal anti‑inflammatory drugs (NSAIDs, including selective COX-2 inhibitors), heparin, immunosuppressants (cyclosporine or tacrolimus) and co-trimoxazole (trimethoprim + sulfamethoxazole).
    • ⓘ Concomitant use with ACE inhibitors or NSAIDs, including selective COX‑2 inhibitors, is accompanied by a lower risk of hyperkalemia, provided careful observance of precautions.
    • ⓘ Nonsteroidal anti‑inflammatory drugs NSAIDs (for example, acetylsalicylic acid in anti-inflammatory dosage regimens, COX-2 inhibitors and non-selective NSAIDs) can reduce the antihypertensive effect of angiotensin II receptor antagonists.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine