Compatibility «Hexavit» and «Calcium-D3 Nycomed»

• Interactions Hexavit with Calcium-D3 Nycomed

  • Dangerous interactions
    • ⓘ With hypervitaminosis of vitamin D₃, it is possible to enhance the action of cardiac glycosides and increase the risk of arrhythmia due to the development of hypercalcemia (it is advisable to control the concentration of calcium in the blood, electrocardiograms, as well as dose adjustment of cardiac glycoside).
    • ⓘ Long-term use of antacids containing aluminum and magnesium in combination with vitamin D₃ may contribute to an increase in the concentration of aluminum and magnesium in the blood and, as a result, the toxic effect of aluminum on bone tissue and hypermagnesemia in patients with renal insufficiency.
    • ⓘ Concomitant use with other vitamin D analogues increases the risk of vitamin D hypervitaminosis.
  • Negative interactions
    • ⓘ Phenytoin, barbiturates, glucocorticoids reduce the effectiveness of vitamin D₃.
    • ⓘ Colestyramine, laxatives (paraffin oil) reduce the absorption of vitamin D₃.
    • ⓘ Simultaneous use with ion-exchange resins such as colestyramine or laxatives can reduce the absorption of vitamin D.
    • ⓘ The combination of calciferol calcium carbonate may increase the toxicity of cardiac glycosides.
    • ⓘ The patient should not take colecalciferol calcium carbonate for 2 hours after taking foods with a high content of oxalic acid (rhubarb, spinach).
    • ⓘ Retinol (vitamin A) (A11CA01) + Antacids and enveloping agents (almagel), vaseline oil => Attenuation of retinol.
    • ⓘ The effect is reduced by diphenin, colestyramine, and vitamin A toxicity.
    • ⓘ Colestyramine, colestipol and mineral oils reduce the absorption of fat‑soluble vitamins in the gastrointestinal tract and require an increase in their dose.
    • ⓘ Ketoconazole can inhibit both biosynthesis and catabolism of 1,25(OH)2‑colecalciferol.
    • ⓘ Vitamin D is an antagonist of drugs used for hypercalcemia: calcitonin, ethidronate, pamidronate, plicamycin, gallium nitrate.
    • ⓘ Simultaneous use of drugs containing phosphates, calcium salts or iron ions is not recommended, since such drugs reduce the absorption of magnesium in the intestine.
  • No interactions
    • ⓘ Vitamin D₃ does not interact with food.
  • Positive interactions
    • ⓘ When used simultaneously with vitamin A, the toxicity of vitamin D decreases.
  • Unclear interactions
    • ⓘ Calcium carbonate + Multivitamins analgin and citramon are used together in More than Multivitamins Lady s formula, More than Multivitamins Man s formula, БОЛЬШЕ ЧЕМ ПОЛИВИТАМИНЫ Kid’s formula.
    • ⓘ Colecalciferol + Multivitamins analgin and citramon are used together in 25 preparations.
    • ⓘ During the course of treatment with GCS, it may be necessary to increase the dose of the combination of colecalciferol + calcium carbonate.
    • ⓘ The use of a combination of calcium carbonate colecalciferol simultaneously with tetracycline is possible either 2 hours before taking tetracycline, or 4-6 hours after.
    • ⓘ With simultaneous administration of sodium fluoride and a combination of calciferol calcium carbonate, the interval between taking the drugs should be at least 3 hours.
    • ⓘ Retinol + Calcium carbonate analgin and citramon are used together in 48 preparations.
    • ⓘ Retinol + Colecalciferol analgin and citramon are used together in 102 preparations.
    • ⓘ Antiepileptic drugs (especially phenytoin and phenobarbital, primidone), rifampicin, colestyramine reduce the reabsorption of vitamin D₃.
    • ⓘ Concomitant therapy with glucocorticosteroids may reduce the effectiveness of vitamin D₃.
    • ⓘ Calcium carbonate + Thiamine analgin and citramon are used together in 29 preparations.
    • ⓘ Colecalciferol + Thiamine analgin and citramon are used together in 67 preparations.
    • ⓘ Riboflavin + Calcium carbonate analgin and citramon are used together in 30 preparations.
    • ⓘ Riboflavin + Colecalciferol analgin and citramon are used together in 65 preparations.
    • ⓘ Nicotinamide + Calcium carbonate analgin and citramon are used together in 67 preparations.
    • ⓘ Nicotinamide + Colecalciferol analgin and citramon are used together in 108 preparations.
    • ⓘ With preparations containing phosphates, calcium salts or iron ions.
    • ⓘ Pyridoxine + Calcium carbonate analgin and citramon are used together in 23 preparations.
    • ⓘ Pyridoxine + Colecalciferol analgin and citramon are used together in 68 preparations.
    • ⓘ Calcium carbonate + Ascorbic acid analgin and citramon are used together in 58 preparations.
    • ⓘ Colecalciferol + Ascorbic acid analgin and citramon are used together in 111 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine