Compatibility «Metypred» and «Prednisolon»

• Interactions Metypred with Prednisolon

  • Dangerous interactions
    • ⓘ The combined use of methylprednisolone and cyclosporine causes mutual inhibition of metabolism and an increase in the likelihood of side effects (cases of seizures have been noted with the combined use of methylprednisolone and cyclosporine).
    • ⓘ Reduces the activity of oral antidiabetic drugs, the effectiveness of vaccines (live vaccines on the background of methylprednisolone can cause disease).
    • ⓘ Seizures have been reported with the simultaneous use of methylprednisolone and cyclosporine.
    • ⓘ This may lead to an increased risk of side effects of salicylate when methylprednisolone is discontinued.
  • Negative interactions
    • ⓘ Methylprednisolone can increase the clearance of acetylsalicylic acid taken in high doses for a long time, which can lead to a decrease in its level in the blood (when methylprednisolone is discontinued, the level of acetylsalicylic acid in the blood increases and the risk of side effects increases).
    • ⓘ Methylprednisolone affects the effect of oral anticoagulants: both an increase and a decrease in the effect of anticoagulants taken simultaneously with methylprednisolone is possible (constant monitoring of coagulation parameters is recommended to maintain the necessary effect of the anticoagulant).
    • ⓘ Ergocalciferol and parathyroid hormone prevent osteopathy caused by methylprednisolone.
    • ⓘ Mitotan and other inhibitors of adrenal cortex function may necessitate an increase in the dose of methylprednisolone.
    • ⓘ In the presence of another CYP3A4 substrate, a change in the hepatic clearance of methylprednisolone may require appropriate dose adjustment of GCS.
    • ⓘ Drugs that inhibit the activity of CYP3A4, such as ketoconazole, erythromycin, clarithromycin, diltiazem and cyclosporine (see table below), usually reduce hepatic clearance and increase plasma concentrations of CYP3A substrates such as methylprednisolone.
    • ⓘ In the presence of a CYP3A4 inhibitor, a lower dose of methylprednisolone may be required to avoid side effects.
    • ⓘ Withdrawal of CYP3A4 inhibitors or inducers may return clinical changes to their original state and require careful dose adjustment of methylprednisolone.
    • ⓘ The table below shows the most frequently noted and/or clinically important interactions of methylprednisolone with other drugs.
    • ⓘ The mutual inhibition of metabolism occurring with the simultaneous use of cyclosporine and methylprednisolone may lead to an increase in the concentration of one or both drugs in blood plasma.
    • ⓘ Therefore, it is necessary to titrate the dose of methylprednisolone in order to avoid the development of its side effects.
    • ⓘ Methylprednisolone may increase the clearance of acetysalicylic acid taken in high doses.
    • ⓘ Prednisolone and Methylprednisolone belong to the same pharmaceutical group: Glucocorticosteroids.
  • No interactions
    • ⓘ The interaction or effect of other drugs when combined with methylprednisolone.
  • Positive interactions
    • ⓘ High doses of methylprednisolone reduce the effectiveness of somatotropin.
    • ⓘ Concomitant use may require an increase in the dose of methylprednisolone to achieve the desired result.
  • Unclear interactions
    • ⓘ Methylprednisolone is a substrate of the cytochrome P450 system and is mainly metabolized by the CYP3A4 isoenzyme, which catalyzes the 6β-hydroxylation of steroids, the main phase of metabolism of endogenous and synthetic GCS.
    • ⓘ Methylprednisolone may increase the rate of acetylation and clearance of isoniazid.
    • ⓘ The effect of methylprednisolone on oral anticoagulants varies.
    • ⓘ Prednisolone + Methylprednisolone analgin and citramon are used together in 5 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,025,223 possible combinations of drugs and their components were found 412,561 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-12-11

Category - medicine