Compatibility «Stavudine» and «Zidovudine+Lamivudine»
Between «Stavudine» and «Zidovudine+Lamivudine» found 2 dangerous and 11 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Zidovudine+Lamivudine |
✘Stavudine Analogs | |
✘Zidovudine+Lamivudine [Zidovudine and more 1Lamivudine] Analogs |
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Interactions Stavudine with Zidovudine+Lamivudine
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Dangerous interactions
Concomitant use of zidovudine with the following drugs that have demonstrated in vitro antagonism to zidovudine should be avoided: stavudine, doxorubicin, nucleoside analogues, for example ribavirin. Stavudine is not recommended to be used simultaneously with the drug zidovudine, since zidovudine can completely inhibit intracellular phosphorylation of stavudine. -
Negative interactions
Thus, the combined use of stavudine and the combination of zidovudine + lamivudine is not recommended. Simultaneous use of zidovudine and stavudine should be avoided, since an antagonistic interaction has been detected in vitro. In vitro studies show that ribavirin reduces phosphorylation of lamivudine, stavudine and zidovudine. However, when using ribavirin and lamivudine (n=18), stavudine (n=10), there was no pharmacokinetic (for example, plasma concentration or intracellular concentration of the triphosphorylated active metabolite) or pharmacodynamic (for example, loss of suppression of HIV-1/hepatitis C virus (HIV-1/HCV) interaction, or zidovudine (n=6) were administered jointly as part of a multi-drug regimen to patients with HIV-1/HCV coinfection (see 'Precautions'). Zidovudine and Stavudine belong to the same pharmaceutical group: Drugs for the treatment of HIV infection. Zidovudine and Stavudine belong to the same pharmaceutical group: Nucleotides reverse transcriptase inhibitors. Zidovudine and Stavudine belong to the same pharmaceutical group: HIV protease inhibitors. However, when using ribavirin and lamivudine (n=18), stavudine (n=10), there was no pharmacokinetic (for example, a change in the plasma concentration of lamivudine or the intracellular concentration of the triphosphorylated active metabolite of lamivudine) or pharmacodynamic (for example, loss of suppression of HIV-1/HCV viruses) interaction, or with the combined use of zidovudine (n=6) as part of a multi-drug regimen for patients with HIV-1/HCV coinfection (see 'Precautions'). Lamivudine and Stavudine belong to the same pharmaceutical group: Drugs for the treatment of HIV infection. Lamivudine and Stavudine belong to the same pharmaceutical group: Nucleotides reverse transcriptase inhibitors. Lamivudine and Stavudine belong to the same pharmaceutical group: HIV protease inhibitors. -
No interactions
Zidovudine can inhibit the process of intracellular phosphorylation of stavudine when used simultaneously. In combination therapy with stavudine with didanosine, lamivudine or nelfinavir, pharmacokinetic interactions between stavudine and these drugs were not observed. However, there were no clinically significant pharmacokinetic interactions when co-administered with lamivudine. -
Unclear interactions
Stavudin. In vitro data show that ribavirin reduces phosphorylation of lamivudine, stavudine and zidovudine.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine