Compatibility «Tramadol» and «Ibuprofen+Codeine phosphate hemihydrate»

• Interactions Tramadol with Ibuprofen+Codeine phosphate hemihydrate

  • Dangerous interactions
    • ⓘ Muscle relaxants: The respiratory depression effect caused by muscle relaxants may complement the main respiratory depression effects associated with the use of opioid painkillers.
    • ⓘ Naloxone: Naloxone suppresses the analgesic effects, CNS depression and respiratory effects of opioid painkillers.
    • ⓘ Codeine (R05DA04) + Opioid narcotic analgesics (N02A) => Dangerous inhibition. (Avoid simultaneous use).
  • Negative interactions
    • ⓘ Diuretics and antihypertensive agents: The antihypertensive effects of diuretics and antihypertensive drugs may be enhanced when combined with opioid painkillers.
    • ⓘ Cimetidine: cimetidine suppresses the metabolism of opioid painkillers, which leads to an increase in their plasma concentrations.
    • ⓘ Naltrexone also blocks the therapeutic effect of opioids.
    • ⓘ Effects on laboratory test results: opioid painkillers affect the results of a number of laboratory tests, including determination of plasma concentrations of amylase, lipase, bilirubin, alkaline phosphatase, LDH, ALT and AST.
    • ⓘ Tramadol and Codeine belong to the same pharmaceutical group: Opioid narcotic analgesics.
  • Unclear interactions
    • ⓘ Opioids can also distort the results of examinations, since they slow down the evacuation of stomach contents, and when visualizing the hepatobiliary system using dysophenin labeled with technetium Tc ^99t, as an opioid drug, there may be a contraction of the Oddi sphincter and an increase in pressure in the bile ducts.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,025,223 possible combinations of drugs and their components were found 412,561 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-12-11

Category - medicine