Compatibility «Methotrexate-Ebewe» and «Pentalginum-N»
Between «Methotrexate-Ebewe» and «Pentalginum-N» found 7 dangerous and 6 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Pentalginum-N |
✘Methotrexate-Ebewe [Methotrexate] Analogs | |
✘Pentalginum-N [Codeine+Caffeine+Metamizole sodium+Naproxen+Phenobarbital and more 5Codeine, Caffeine, Metamizole sodium, Naproxen, Phenobarbital] Analogs |
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Interactions Methotrexate-Ebewe with Pentalginum-N
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Dangerous interactions
NSAIDs should not be prescribed before or simultaneously with high doses of methotrexate. It has been reported that the simultaneous use of certain NSAIDs with high doses of methotrexate increases and prolongs the concentration of methotrexate in serum, which can lead to death from severe hematological (including suppression of bone marrow function and aplastic anemia) and gastrointestinal toxicity. Animal studies have shown that NSAIDs reduce the tubular secretion of methotrexate and can increase its toxicity by increasing the concentration of methotrexate in the blood. The possibility of increased hepatotoxicity when prescribing methotrexate with other hepatotoxic drugs has not been evaluated. Therefore, patients receiving methotrexate and other potentially hepatotoxic drugs together (for example, leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored due to a possible increased risk of hepatotoxicity. Other drugs that cause inhibition of bone marrow function or radiation therapy potentiate the effect and additively inhibit bone marrow function. Cytostatic agents, Azathioprine, mercaptopurine, methotrexate + Phenobarbital => Increased effect of cyclophosphamide up to toxic. -
Negative interactions
Myelotoxic drugs enhance the manifestation of hematotoxicity of sodium metamizole. NSAIDs have been reported to competitively inhibit the accumulation of methotrexate in rabbit kidney slices. This may indicate that they may enhance the toxicity of methotrexate. Caution should be exercised when using NSAIDs with methotrexate at the same time. Concomitant use of naproxen and pemetrexed may increase the risk of pemetrexed-related myelosuppression, renal and gastrointestinal toxicity. With the simultaneous use of naproxen and pemetrexed in patients with renal insufficiency, whose creatinine Cl ranges from 45 to 79 ml/min, it is necessary to monitor myelosuppression, renal and gastrointestinal toxicity. -
No interactions
Despite the possibility of interaction, studies of methotrexate in patients with rheumatoid arthritis, usually with simultaneous administration of NSAIDs in fixed doses, have not revealed any obvious problems. -
Positive interactions
The increased and prolonged effect of methotrexate, leading to intoxication, is facilitated by the simultaneous use of NSAIDs, barbiturates, sulfonamides, corticosteroids, tetracyclines, trimethoprim, chloramphenicol, paraaminobenzoic and paraaminohippuric acids, probenecid. The addition of sodium metamizole to methotrexate treatment may enhance the hematotoxic effect of methotrexate, especially in elderly patients. -
Unclear interactions
НПВС. Hepatotoxic drugs. With myelotoxic drugs. With methotrexate. Methotrexate. Cytostatics -.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine