Vaccininum

 The lymph from the cow-pox. Preparation: Triturations.

 Restlessness. A slight but definite feeling of general malaise (third day); increase of the feelings of yesterday (fourth day); oppressive increase (fifth day). Some languor, lassitude, and restlessness (fifth day); much increased (sixth, seventh, eighth, and ninth days).

 Ill-humor with restless sleep (second day).

 Slight frontal headache (sixth day); much increased (seventh, eighth, and ninth days).

 Dry mouth and tongue (fifth day); much increased (sixth), seventh, eighth, and ninth days).

 Appetite gone, and disgust to taste, smell, and appearance of food (ninth day).

 Backache (sixth day); much increased (seventh, eighth, and ninth days).
 Extremities.
 Slight but distinctly marked soreness of the lower extremities, as if heated or overexerted (sixth day); aching of the lower extremities, amounting to an almost unfitness to get about in the performance of my daily avocation, and which cannot be better described than by the appellation of a break bone sensation, i.
 E., my legs ached immoderately, and to the aching was conjoined a sensation as if the bones were undergoing the process of comminution (seventh day).

 Fever, with heat, thirst, tossing about, crying, aversion to food (three to four days). Skin hot and dry (ninth day).

 Skin.
 A general eruption similar to cow-pox, from which other children were successfully vaccinated. Small pimples developed at the point of vaccination (ordinary vaccination, after six weeks, was unsuccessful). Red pimples or blotches on various parts, most evident when warm (after two or three days). On the fourth day there developed on the face small bright-red pimples, which on the following day formed vesicles of a pearly look, with depressed tips, and surrounded by red areolae; on the eighth day the child was very restless, screamed and cried, and would not be quiet, wished to be carried constantly; was sleepless, with febrile heat, rapid pulse, thirst, desire to nurse constantly without taking much; constipation, high-colored urine; the pocks were elastic, tense, hard, pearly; with inflamed redness and swelling of the rest of the face; on the tenth day the inflammation and swelling of the face disappeared, the child became quiet, and the fever diminished; on the forehead and nose the pocks became, confluent, looked turbid, were filled with purulent liquid, and somewhat shriveled; on the eleventh day the pustules burst and discharges a purulent matter, which formed yellowish-brown scabs, which afterwards became dark; these suppurated and exuded for a long time, gradually healed in about fourteen days; the whole course was like that of crusta lactea; the child was very well afterwards, but still had on the forehead and cheeks some small, very white spots without scars, subsequently repeated vaccinations at six months intervals were ineffectual. Small red pimples in various parts on the skin (subsequently repeated vaccination was ineffectual). A tingling burning sensation in the skin, over the whole body, similar to the sensation of an eruption of fever blisters on the lips, nose, cheek, etc., the sensation being very and most intense in the skin of the forehead, and of the lower and anterior portion of hairy scalp, which, on examination in a mirror, revealed the fact that those portion of the skin were tinged with a scarlet blush, or efflorescence, precisely similar in appearance to that which I have always seen as the most immediate precursor and certain of an immediate variolous eruption (ninth day).

 More activity of arterial action (ninth day). More actual manifestation of febrile of heart and arteries than on any of the preceding days (eighth day).

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• — Psorinoheel n (Сигнал НЦ ФГУП )