Compatibility «Paracetamol+Tramadol» and «Indomethacin»

• Interactions Paracetamol+Tramadol with Indomethacin

  • Dangerous interactions
    • ⓘ Prolonged combined use of paracetamol and other NSAIDs increases the risk of developing 'analgesic' nephropathy and renal papillary necrosis, the onset of end-stage renal failure.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
    • ⓘ Increases (mutually) the risk of side effects (primarily gastrointestinal lesions) of other NSAIDs.
    • ⓘ Combined use with paracetamol increases the risk of nephrotoxicity.
    • ⓘ Tramadol in the form of an injection solution is pharmaceutically incompatible with injectable solutions of diclofenac, indomethacin, phenylbutazone, diazepam, flunitrazepam, midazolam, nitroglycerin.
  • Negative interactions
    • ⓘ Inducers of microsomal oxidation (in pm carbamazepine, phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the analgesic effect and its duration.
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Paracetamol and Indomethacin belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ Inducers of microsomal oxidation (in pm carbamazepine, barbiturates) reduce the severity of the analgesic effect of tramadol and the duration of action.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine