Compatibility «Amitriptyline» and «Drotaverine+Codeine+Paracetamol»

• Interactions Amitriptyline with Drotaverine+Codeine+Paracetamol

  • Dangerous interactions
    • ⓘ Amitriptyline (N06AA09) + Opioid narcotic analgesics (N02A) => Dangerous inhibition occurs. The narcotic effect increases.
    • ⓘ Amitriptyline; Imipramine(N06AA) + Opioid narcotic analgesics(N02A) => Respiratory depression. The effects of opioid analgesics are potentiated. (These drugs should be used together with caution and only in small doses).
    • ⓘ Tricyclic antidepressants (N06A) + Narcotic analgesics => Respiratory depression.
    • ⓘ Opioid narcotic analgesics (N02A) + Amitriptyline; Imipramine(N06AA) => Respiratory depression.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
  • Negative interactions
    • ⓘ Drugs capable of inducing liver enzymes (salicylamide, barbiturates, antiepileptic drugs, tricyclic antidepressants, alcohol, rifampicin) - an increase in the concentration of toxic metabolites of paracetamol is possible.
    • ⓘ Drugs that have a depressing effect on the central nervous system (hypnotics, drugs for anesthesia, narcotic analgesics, sedatives, anxiolytics, tricyclic antidepressants and antipsychotics).
    • ⓘ Increases the risk of arterial hypotension caused by tricyclic antidepressants, quinidine and procainamide (novocainamide).
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
  • Positive interactions
    • ⓘ It enhances (especially with intravenous administration) the effect of other antispasmodics (in pm m-cholinoblockers), hypotension caused by tricyclic antidepressants, quinidine, novocainamide.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine