Compatibility «Pregabalin» and «Codeine+Caffeine+Paracetamol»

• Interactions Pregabalin with Codeine+Caffeine+Paracetamol

  • Dangerous interactions
    • ⓘ Opioid narcotic analgesics (N01AH01) + CNS depressants; hypnotics, neuroleptics, benzodiazepine tranquilizers, etc. => Respiratory depression, bradycardia, deep coma, possible death.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
  • Negative interactions
    • ⓘ Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, which negatively affect liver function.
    • ⓘ It has also been reported about the negative effect of pregabalin on gastrointestinal functions (in pm, the development of intestinal obstruction, paralytic ileus, constipation) when used concomitantly with drugs that cause constipation (such as opioids, see 'Precautions').
  • Positive interactions
    • ⓘ Codeine can potentiate the effect of drugs that depress the central nervous system (including alcohol); however, this effect is insignificant when it is quantitatively contained in this dosage form of the combination codeine + caffeine + paracetamol.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine