Compatibility «Warfarin» and «Acetylsalicylic acid+Caffeine+Paracetamol»

• Interactions Warfarin with Acetylsalicylic acid+Caffeine+Paracetamol

  • Dangerous interactions
    • ⓘ The risk of bleeding increases with the simultaneous use of NSAIDs and warfarin.
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics¹ (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants¹, antidepressants¹, intravaginal and systemic antifungal drugs¹, antimalarial drugs, antitumor drugs¹, antiparasitic and antimicrobial drugs¹, platelet aggregation inhibitors, antiteroid drugs¹, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics¹, drugs that regulate the acidity of gastric juice and anti-ulcer drugs¹, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs¹, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)¹, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins¹.
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: steroid inhibitors of the adrenal cortex, antacids, sedatives, antiarrhythmic drugs¹, antibiotics¹, anticonvulsants¹, antidepressants¹, antifungal drugs of systemic action¹, antihistamines, antitumor drugs¹, neuroleptics, antireoid agents¹, barbiturates, diuretics¹, enteral dietary supplements , enzyme inhibitors, drugs for the regulation of gastric acidity and treatment of peptic ulcer¹, hypnotic drugs¹, immunosuppressants, lipid-lowering drugs (bile acid sequestrants, HMG-CoA reductase inhibitors)¹, drugs of natural origin, oral contraceptives, selective estrogen receptor modulators, adrenocorticosteroids, anti-tuberculosis drugs¹, vitamins¹.
    • ⓘ Irregular intake of paracetamol has no significant effect on the effect of anticoagulants.
  • Negative interactions
    • ⓘ Careful monitoring of patients receiving NSAIDs is recommended to ensure that no dose adjustment of anticoagulants is required.
    • ⓘ Medicinal products of natural origin containing salicylate and/or having antiplatelet properties: agrimony¹, aloe gel, aspen poplar (Populus tremuloides), carpal bug (Cimicifuga racemosa), plum-leaved Viburnum (prunifolium), trefoil watch (trifolium)², cassia⁴, clove (Eugenia caryophyllus), cranberry, dandelion officinalis⁴, pyrethrum girlish (tansy girlish) (Chrysanthemum parthenium), garlic⁵ (Allium sativum), German Sarsaparilla (German Sarsaparilla), sandy sedge (Carex arenaria), ginger, ginkgo biloba, ginseng⁵ (Panax spp.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ INR should be monitored during and after the end of simultaneous use of paracetamol (especially in high doses and/ or for a long time) and coumarin derivatives.
    • ⓘ If necessary, the dose of anticoagulants is adjusted.
  • Positive interactions
    • ⓘ Indirect anticoagulants (B01A) (neodicumarin, syncumar, phenyline, etc.) + Allopurinol, isoniazid, MAO inhibitors, levomycetin, mephenamic acid, octadine, paracetamol, teturam, cimetidine => Increased anticoagulant effect up to hemorrhagic syndrome.
  • Unclear interactions
    • ⓘ Platelet antiplatelet agents.
    • ⓘ ¹ They contain coumarins, have antiplatelet properties and may have coagulant properties due to the possible content of vitamin K.
    • ⓘ ² They contain coumarins and salicylates.
    • ⓘ ⁴ They contain coumarins and have antiplatelet properties.
    • ⓘ ⁵ Have antiplatelet and fibrinolytic properties.
    • ⓘ Anticoagulants (e.g. coumarin, heparin, warfarin), antiplatelet agents (e.g. clopidogrel and dipyridamole) and SSRIs (e.g. setralin or paroxetine).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine