Compatibility «Bisoprolol» and «Ivabradine+Metoprolol»

• Interactions Bisoprolol with Ivabradine+Metoprolol

  • Dangerous interactions
    • ⓘ - beta-blockers (for example, in the form of eye drops) and MAO inhibitors - careful monitoring of the condition of patients is recommended, etc.; when used simultaneously with beta-blockers, the risk of developing bradycardia and increased hypotensive effect increases;.
  • Negative interactions
    • ⓘ In this regard, during treatment with beta-blockers, intravenous administration of BCC is contraindicated (see 'Contraindications').
    • ⓘ The sudden withdrawal of such drugs, especially if it preceded the withdrawal of the beta-blocker, may increase the risk of developing withdrawal syndrome.
    • ⓘ In the case of simultaneous use of clonidine, its administration should be continued for some time in case of withdrawal of the beta-blocker.
    • ⓘ Beta-blockers can enhance the negative inotropic effect of antiarrhythmic drugs and increase the time of atrial conduction.
    • ⓘ Inhaled anesthetics increase bradycardia in patients taking beta-blockers.
    • ⓘ - cardiac glycosides (digoxin), when taken simultaneously with beta-blockers, can slow down the rate of AV conduction and cause bradycardia;.
    • ⓘ In clinical studies, there was no change in the safety profile when using ivabradine with ACE inhibitors, ARA II, beta-blockers, diuretics, aldosterone antagonists, short- and prolonged-acting nitrates, HMG-CoA reductase inhibitors, fibrates, proton pump inhibitors, hypoglycemic agents for oral administration, acetylsalicylic acid and other antiplatelet agents.
    • ⓘ The risk of developing bradycardia increases with simultaneous administration of drugs that slow down the heart rate (for example, digoxin, amiodarone, beta-blockers).
    • ⓘ Ivabradine was used in combination with ACE inhibitors, angiotensin II receptor antagonists, beta-blockers, diuretics, aldosterone antagonists, short- and long-acting nitrates, HMG-CoA reductase inhibitors, fibrates, proton pump inhibitors, hypoglycemic agents for oral administration, acetylsalicylic acid and other antiplatelet agents.
    • ⓘ Bisoprolol and Metoprolol belong to the same pharmaceutical group: Beta blockers.
    • ⓘ Bisoprolol and Metoprolol belong to the same pharmaceutical group: Beta-blockers are selective.
  • Positive interactions
    • ⓘ BCCs such as verapamil or diltiazem, when administered intravenously, can enhance the hypotensive effect of beta-blockers, exacerbating the effect on heart rate, AV conduction and myocardial contractility.
  • Unclear interactions
    • ⓘ - epinephrine - if, under certain circumstances, patients receiving beta-blockers need to be injected with epinephrine, it should be borne in mind that the hypotensive effect is significantly less pronounced in cardioselective beta-blockers than in non-selective ones;.
    • ⓘ Floctafenin beta-blockers may interfere with the compensatory reaction from the CCC associated with arterial hypotension or shock, which may develop against the background of floctafenin.
    • ⓘ Beta-blockers are also prescribed.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,036,109 possible combinations of drugs and their components were found 412,572 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-04-16

Category - medicine