Compatibility «Fentanyl» and «Paracetamol+Tramadol»

• Interactions Fentanyl with Paracetamol+Tramadol

  • Dangerous interactions
    • ⓘ It enhances the effect of drugs that depress the central nervous system (in pm, tranquilizers, hypnotics, sedatives and anesthetics), and ethanol.
  • Negative interactions
    • ⓘ Concomitant use with opioid antagonist agonists (buprenorphine, nalbufin, pentazocine) is not recommended, etc.; the analgesic effect decreases as a result of competitive interaction with receptors, and there is a risk of withdrawal syndrome.
    • ⓘ Inducers of microsomal oxidation (in pm carbamazepine, phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the analgesic effect and its duration.
    • ⓘ With antagonistic agonists or partial agonists of opioid receptors (buprenorphine, nalbufin, pentazocin).
    • ⓘ With other drugs that depress the central nervous system, such as other opioids (including antitussives and drugs for the treatment of withdrawal syndrome), barbiturates, benzodiazepines, anxiolytics, hypnotics, antidepressants with sedative effect, H₁‑receptor blockers with sedative effect, neuroleptics, antihypertensive drugs with The central mechanism of action is thalidomide and baclofen.
    • ⓘ Inducers of microsomal oxidation (in pm carbamazepine, barbiturates) reduce the severity of the analgesic effect of tramadol and the duration of action.
    • ⓘ Tramadol and Fentanyl belong to the same pharmaceutical group: Opioid narcotic analgesics.
  • Positive interactions
    • ⓘ Alcohol potentiates the sedative effect of opioid analgesics, impaired concentration, ability to drive vehicles and work with mechanisms.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine