Compatibility «Phenobarbital» and «Drotaverine+Caffeine+Naproxen+Paracetamol+Pheniramine»

• Interactions Phenobarbital with Drotaverine+Caffeine+Naproxen+Paracetamol+Pheniramine

  • Dangerous interactions
    • ⓘ With the simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, alcohol, it is possible to increase the depressive effect on the central nervous system.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Hypnotics, Barbiturates, glutetimide, nitrazepam, etc. + Antihistamines with a sedative component (diphedrol, diprazine, suprastin), antihypertensive agents (clofelin, reserpine), neuroleptics (aminazine, haloperidol), tranquilizers (sibazone) => Increased hypnotic effect up to toxic.
  • Negative interactions
    • ⓘ With the combined use of caffeine and barbiturates, primidone, anticonvulsants (derivatives of hydantoin, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; with simultaneous administration of caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin, a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing concentration in the blood).
  • No interactions
    • ⓘ Hypnotics; Sedatives (N05C) + Respiratory stimulants (R07AB, N06BC) => Respiratory analeptics are used for poisoning with hypnotics and sedatives..
  • Positive interactions
    • ⓘ Phenobarbital increases the reliability of spasm elimination.
    • ⓘ Phenobarbital enhances the antispasmodic effect of drotaverine.
  • Unclear interactions
    • ⓘ Phenobarbital + Caffeine analgin and citramon are used together in 22 preparations.
    • ⓘ Phenobarbital + Naproxen analgin and citramon are used together in Pentalginum-N, Pyralgin, Pentanov-H.
    • ⓘ Phenobarbital + Paracetamol analgin and citramon are used together in 10 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine