Compatibility «Xarelto» and «Enoxaparin sodium»

• Interactions Xarelto with Enoxaparin sodium

  • Dangerous interactions
    • ⓘ The simultaneous use of enoxaparin sodium, warfarin, acetylsalicylic acid, clopidogrel and the constant use of NSAIDs may increase the risk of bleeding.
  • Negative interactions
    • ⓘ In an interaction study, single doses of enoxaparin sodium (40 mg n/a) and rivaroxaban (10 mg), used simultaneously, led to an additive effect on anti-factor activity.
    • ⓘ After simultaneous use of enoxaparin (40 mg once) with Xarelto (10 mg once), a cumulative effect was observed associated with an overwhelming effect on the activity of factor Xa without any additional effect on coagulation parameters (PV, ACTV).
    • ⓘ Enoxaparin sodium and Rivaroxaban belong to the same pharmaceutical group: Anticoagulants.
  • No interactions
    • ⓘ Neither enoxaparin sodium nor warfarin affected the pharmacokinetics of rivaroxaban.
    • ⓘ Enoxaparin does not affect the pharmacokinetics of rivaroxaban (see 'Special instructions').
    • ⓘ Simultaneous administration of omeprazole proton pump inhibitor, H₂-histamine receptor antagonist ranitidine, aluminum hydroxide/magnesium hydroxide antacid, naproxen, clopidogrel or enoxaparin has no effect on the bioavailability and pharmacokinetics of rivaroxaban.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine