Compatibility «Valsacor» and «Indap»

• Interactions Valsacor with Indap

  • Dangerous interactions
    • ⓘ Concomitant administration of thiazide diuretics, including hydrochlorothiazide, may increase the risk of side effects of amantadine.
    • ⓘ When using iodine contrast agents in high doses against a background of reduced BCC due to the use of diuretics, there is an increased risk of acute renal failure.
    • ⓘ In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ Indapamide (C03BA11) + Thiazide diuretics (C03A) => Increases the likelihood of hypokalemia. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown).
  • Negative interactions
    • ⓘ With the simultaneous use of lithium preparations with ACE and ARA II inhibitors or thiazide diuretics, a reversible increase in the concentration of lithium in blood plasma and an associated increase in toxic manifestations were noted.
    • ⓘ The risk of toxic manifestations associated with the use of lithium preparations may further increase when used concomitantly with Valz H, since the renal clearance of lithium preparations decreases under the influence of thiazide diuretics.
    • ⓘ Antihypertensive drugs.
    • ⓘ When used concomitantly with ACE inhibitors and diuretics, cases of reversible increases in the plasma concentration of lithium and its toxic effects have been reported.
    • ⓘ Other antihypertensive drugs.
    • ⓘ The risk of hypokalemia caused by diuretics may increase with the simultaneous use of corticosteroids, laxatives, ACTH, amphotericin B, carbenoxolone, penicillin, acetylsalicylic acid or its derivatives and antiarrhythmic drugs.
    • ⓘ The hyponatremic effect caused by diuretics may be enhanced when used concomitantly with antidepressants, antipsychotics, anticonvulsants (carbamazepine).
    • ⓘ Thiazide diuretics may alter glucose tolerance, which may require correction of doses of insulin and oral hypoglycemic agents.
    • ⓘ Concomitant administration of thiazide diuretics, in pm hydrochlorothiazide, with beta-blockers may increase the risk of hyperglycemia.
    • ⓘ Thiazide diuretics, in pm hydrochlorothiazide, can enhance the hyperglycemic effect of diazoxide.
    • ⓘ Simultaneous administration of thiazide diuretics, in pm hydrochlorothiazide, may increase the frequency of hypersensitivity reactions to allopurinol.
    • ⓘ Hypokalemia and hypomagnesemia (undesirable effects of thiazide diuretics) may contribute to the development of cardiac arrhythmias in patients receiving cardiac glycosides.
    • ⓘ The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs.
    • ⓘ In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy.
    • ⓘ Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted.
    • ⓘ Indapamide and Hydrochlorothiazide belong to the same pharmaceutical group: Thiazide diuretics.
  • Positive interactions
    • ⓘ Thiazide diuretics enhance the antihypertensive effect of other antihypertensive drugs (including guanethidine, methyldopa, beta-blockers, vasodilators, BMCC, ACE inhibitors, ARA II, renin inhibitors).
    • ⓘ Thiazide diuretics, including hydrochlorothiazide, potentiate the action of non-depolarizing muscle relaxants.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine