Compatibility «Aevit in capsules» and «Calcemin Advance»

• Interactions Aevit in capsules with Calcemin Advance

  • Dangerous interactions
    • ⓘ With hypervitaminosis of vitamin D₃, it is possible to enhance the action of cardiac glycosides and increase the risk of arrhythmia due to the development of hypercalcemia (it is advisable to control the concentration of calcium in the blood, electrocardiograms, as well as dose adjustment of cardiac glycoside).
    • ⓘ Long-term use of antacids containing aluminum and magnesium in combination with vitamin D₃ may contribute to an increase in the concentration of aluminum and magnesium in the blood and, as a result, the toxic effect of aluminum on bone tissue and hypermagnesemia in patients with renal insufficiency.
    • ⓘ Concomitant use with other vitamin D analogues increases the risk of vitamin D hypervitaminosis.
  • Negative interactions
    • ⓘ Calcium salts can interact with many substances due to changes in the pH of gastric juice, the effect on gastric emptying or the formation of complexes with certain substances, which leads to a decrease in the absorption of both substances.
    • ⓘ It is recommended to monitor serum calcium levels in people taking calcium and/or vitamin D or these drugs at the same time.
    • ⓘ Some medications may reduce gastrointestinal absorption of vitamin D.
    • ⓘ To minimize such interaction, it is necessary to use these drugs and vitamin D separately, at least 2 hours before or 4-6 hours after taking vitamin D.
    • ⓘ These drugs: ion exchange resins (in pm cholestyramine), laxatives, orlistat, carbamazepine, phenytoin and barbiturates accelerate the conversion of vitamin D into its inactive metabolite, reducing the effect of vitamin D₃.
    • ⓘ The effect is reduced by diphenin, colestyramine, and vitamin A toxicity.
    • ⓘ Colestyramine, colestipol and mineral oils reduce the absorption of fat‑soluble vitamins in the gastrointestinal tract and require an increase in their dose.
    • ⓘ Ketoconazole can inhibit both biosynthesis and catabolism of 1,25(OH)2‑colecalciferol.
    • ⓘ Vitamin D is an antagonist of drugs used for hypercalcemia: calcitonin, ethidronate, pamidronate, plicamycin, gallium nitrate.
    • ⓘ Retinol (vitamin A) (A11CA01) + Antacids and enveloping agents (almagel), vaseline oil => Attenuation of retinol.
  • No interactions
    • ⓘ Vitamin D₃ does not interact with food.
  • Unclear interactions
    • ⓘ Vitamin E + Colecalciferol analgin and citramon are used together in 141 preparations.
    • ⓘ Vitamin E + Calcium citrate analgin and citramon are used together in LifePak, LifePak+.
    • ⓘ Vitamin E + Calcium carbonate analgin and citramon are used together in 69 preparations.
    • ⓘ Vitamin E + Magnesium oxide analgin and citramon are used together in 29 preparations.
    • ⓘ Vitamin E + Zinc oxide analgin and citramon are used together in 30 preparations.
    • ⓘ Calcium salts.
    • ⓘ Retinol + Colecalciferol analgin and citramon are used together in 102 preparations.
    • ⓘ Antiepileptic drugs (especially phenytoin and phenobarbital, primidone), rifampicin, colestyramine reduce the reabsorption of vitamin D₃.
    • ⓘ Concomitant therapy with glucocorticosteroids may reduce the effectiveness of vitamin D₃.
    • ⓘ Retinol + Calcium citrate analgin and citramon are used together in LifePak, LifePak+.
    • ⓘ Retinol + Calcium carbonate analgin and citramon are used together in 48 preparations.
    • ⓘ Retinol + Magnesium oxide analgin and citramon are used together in 18 preparations.
    • ⓘ Retinol + Zinc oxide analgin and citramon are used together in 25 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine