Compatibility «Amlodipine+Lisinopril» and «Candiderm»

• Interactions Amlodipine+Lisinopril with Candiderm

  • Dangerous interactions
    • ⓘ Allopurinol, procainamide, cytostatics or immunosuppressants (systemic GCS) may lead to an increased risk of leukopenia when used concomitantly with ACE inhibitors.
    • ⓘ Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
    • ⓘ Regardless of the status of the CYP3A5 genotype, the possibility of interaction with these drugs cannot be excluded.
  • Negative interactions
    • ⓘ Reduction of antihypertensive effect (retention of fluid and sodium ions as a result of the action of corticosteroids).
    • ⓘ Inhibitors of the CYP3A4 isoenzyme: studies in elderly patients have shown that diltiazem inhibits the metabolism of amlodipine, probably through the CYP3A4 isoenzyme (plasma/serum concentration increases by almost 50% and the effect of amlodipine increases).
    • ⓘ It is possible that stronger inhibitors of the CYP3A4 isoenzyme (e.g. ketoconazole, itraconazole, ritonavir) may increase the concentration of amlodipine in the blood serum to a greater extent than diltiazem.
    • ⓘ Inducers of the CYP3A4 isoenzyme: simultaneous use with antiepileptic drugs (e.g. carbamazepine, phenobarbital, phenytoin, phosphenytoin, primidone), rifampicin, drugs containing St. John's wort may lead to a decrease in the concentration of amlodipine in blood plasma.
    • ⓘ Control with possible dose adjustment of amlodipine is indicated during treatment with inducers of the CYP3A4 isoenzyme and after their withdrawal.
    • ⓘ Clarithromycin is an inhibitor of the CYP3A4 isoenzyme.
    • ⓘ Reduction of the antihypertensive effect of amlodipine (due to fluid retention and sodium ions as a result of the action of corticosteroids).
    • ⓘ However, a 3-fold increase in plasma exposure to tacrolimus was reported in a kidney transplant patient (non-CYP3A5 expressor) after starting amlodipine for the treatment of post-transplant hypertension, which led to a decrease in the dose of tacrolimus.
    • ⓘ Inhibitors of the CYP3A4 isoenzyme.
    • ⓘ Allopurinol, procainamide, cytostatics, immunosuppressants, GCS (with systemic use).
  • No interactions
    • ⓘ Since amlodipine is a weak inhibitor of CYP3A4, the exposure of mTOR inhibitors may increase when used together.
  • Positive interactions
    • ⓘ A prospective study involving healthy volunteers from China (n=9), CYP3A5 expressers, showed an increase in tacrolimus exposure by 2.5-4 times when used concomitantly with amlodipine compared with the use of tacrolimus alone.
  • Unclear interactions
    • ⓘ Corticosteroids (mineralocorticosteroids and GCS), tetracosactide.
    • ⓘ Corticosteroids (mineral.
    • ⓘ And glucocorticosteroids), tetracosactide.
    • ⓘ This result was not observed in individuals who did not express CYP3A5 (n=6).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine