Compatibility «Gliclazide» and «Metformin»
Between «Gliclazide» and «Metformin» found 7 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Metformin |
✘Gliclazide Analogs | |
✘Metformin [Metformin and more 1Metformin hydrochloride] Analogs |
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Interactions Gliclazide with Metformin
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Dangerous interactions
In addition, despite the fact that gliclazide is not approved for use with other antidiabetic agents, hypoglycemia increases when gliclazide is used in combination with other antidiabetic drugs. Other antidiabetic drugs (insulins, acarbose, biguanides) increase the risk of hypoglycemia, enhancing the effect of lowering blood glucose levels. Beta-blockers increase the risk of hypoglycemia, enhancing the effect of lowering blood glucose levels. H2-antihistamines increase the risk of hypoglycemia, enhancing the effect of lowering blood glucose levels. Sulfonamides increase the risk of hypoglycemia, enhancing the effect of lowering blood glucose levels. NSAIDs increase the risk of hypoglycemia, enhancing the effect of lowering blood glucose levels. Ethanol-containing drugs increase the risk of hypoglycemia. -
Negative interactions
With the simultaneous use of metformin with sulfonylurea derivatives, insulin, acarbose, salicylates, hypoglycemia may develop. The hypoglycemic effect of metformin can be reduced by phenothiazides, glucagon, estrogens, oral contraceptives, phenytoin, sympathomimetics, nicotinic acid, isoniazid, blockers of 'slow' calcium channels, sodium levothyroxine. Hypoglycemia as a result of drug interaction may increase with the simultaneous use of sulfonylurea derivatives with drugs such as long-acting sulfonamides, tuberculostatics, NSAIDs, fibrates, MAO inhibitors, salicylates, probenecid, beta-blockers, azole antifungal drugs (for oral and parenteral use), antagonists of H2-antihistamines receptors, ACE inhibitors and clarithromycin. Barbiturates should be used with caution in patients receiving oral hypoglycemic drugs, as they can reduce the hypoglycemic effect. Discontinuation of such drugs in patients receiving metformin requires careful monitoring of their condition due to the possibility of hypoglycemia. -
Unclear interactions
Metformin + Gliclazide analgin and citramon are used together in Glimekomb.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine