Compatibility «Indapamide» and «Valsacor»
Between «Indapamide» and «Valsacor» found 6 dangerous and 29 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Valsacor |
✘Indapamide Analogs | |
✘Valsacor [Valsartan+Hydrochlorothiazide and more 2Valsartan, Hydrochlorothiazide] Analogs |
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Interactions Indapamide with Valsacor
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Dangerous interactions
Concomitant administration of thiazide diuretics, including hydrochlorothiazide, may increase the risk of side effects of amantadine. When using iodine contrast agents in high doses against a background of reduced BCC due to the use of diuretics, there is an increased risk of acute renal failure. In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure. Indapamide (C03BA11) + Thiazide diuretics (C03A) => Increases the likelihood of hypokalemia. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown). It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Hypokalemia and hypomagnesemia caused by the action of thiazide diuretics increase the toxicity of cardiac glycosides. -
Negative interactions
With the simultaneous use of lithium preparations with ACE and ARA II inhibitors or thiazide diuretics, a reversible increase in the concentration of lithium in blood plasma and an associated increase in toxic manifestations were noted. The risk of toxic manifestations associated with the use of lithium preparations may further increase when used concomitantly with Valz H, since the renal clearance of lithium preparations decreases under the influence of thiazide diuretics. Antihypertensive drugs. When used concomitantly with ACE inhibitors and diuretics, cases of reversible increases in the plasma concentration of lithium and its toxic effects have been reported. Other antihypertensive drugs. Thiazide diuretics enhance the antihypertensive effect of other antihypertensive drugs (including guanethidine, methyldopa, beta-blockers, vasodilators, BMCC, ACE inhibitors, ARA II, renin inhibitors). The risk of hypokalemia caused by diuretics may increase with the simultaneous use of corticosteroids, laxatives, ACTH, amphotericin B, carbenoxolone, penicillin, acetylsalicylic acid or its derivatives and antiarrhythmic drugs. The hyponatremic effect caused by diuretics may be enhanced when used concomitantly with antidepressants, antipsychotics, anticonvulsants (carbamazepine). Thiazide diuretics may alter glucose tolerance, which may require correction of doses of insulin and oral hypoglycemic agents. Concomitant administration of thiazide diuretics, in pm hydrochlorothiazide, with beta-blockers may increase the risk of hyperglycemia. Thiazide diuretics, in pm hydrochlorothiazide, can enhance the hyperglycemic effect of diazoxide. Simultaneous administration of thiazide diuretics, in pm hydrochlorothiazide, may increase the frequency of hypersensitivity reactions to allopurinol. Hypokalemia and hypomagnesemia (undesirable effects of thiazide diuretics) may contribute to the development of cardiac arrhythmias in patients receiving cardiac glycosides. The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs. In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy. Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted. Indapamide and Hydrochlorothiazide belong to the same pharmaceutical group: Thiazide diuretics. Thiazides can reduce plasma levels of iodine bound to proteins. Thiazides should be discontinued before parathyroid function tests are performed. It may be necessary to adjust the dose of simultaneously prescribed antihypertensive drugs. Thiazide diuretics affect glucose tolerance (hyperglycemia may develop) and reduce the effectiveness of hypoglycemic agents (dose adjustment of hypoglycemic agents may be required). Concomitant use of thiazide diuretics (including hydrochlorothiazide), with beta‑blockers or diazoxide may increase the risk of hyperglycemia. It may be necessary to adjust the dose of uricosuric drugs, since hydrochlorothiazide increases the concentration of uric acid in the blood serum. Thiazide diuretics may increase the frequency of hypersensitivity reactions to allopurinol. Thiazide diuretics (including hydrochlorothiazide) can reduce the clearance of amantadine, lead to an increase in the concentration of amantadine in blood plasma and increase the risk of its undesirable effects. Anticholinergic drugs (for example, atropine, biperiden) increase the bioavailability of thiazide diuretics by reducing the motility of the gastrointestinal tract and the rate of gastric emptying. Thiazide diuretics reduce the renal excretion of cytotoxic drugs (e.g. cyclophosphamide and methotrexate) and potentiate their myelosuppressive effect. With the simultaneous use of thiazide diuretics and cyclosporine, the risk of hyperuricemia and exacerbation of gout increases. Thiazide diuretics may reduce the effect of oral anticoagulants. Dehydration of the body while taking thiazide diuretics increases the risk. -
Positive interactions
Thiazide diuretics, including hydrochlorothiazide, potentiate the action of non-depolarizing muscle relaxants. When used concomitantly with thiazide diuretics, hyponatremia may be potentiated.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine