Compatibility «Otipax» and «Kombinil-Duo»
Between «Otipax» and «Kombinil-Duo» found 5 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Kombinil-Duo |
✘Otipax [Lidocaine+Phenazone and more 2Lidocaine, Phenazone] Analogs | |
✘Kombinil-Duo [Dexamethasone and more 1Ciprofloxacin] Analogs |
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Interactions Otipax with Kombinil-Duo
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Dangerous interactions
Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs. Prolonged simultaneous use of NSAIDs and GCS should be avoided due to an increased risk of adverse events from the gastrointestinal tract and impaired water-electrolyte balance. Increases the nephrotoxicity of cyclosporine, the risk of increased central nervous system excitability and convulsive reactions against the background of NSAIDs. The combination of very high doses of quinolones and NSAIDs (excluding acetylsalicylic acid) can provoke seizures; it should be used with caution. Quinolones (J01M)/ Fluoroquinolones (J01MA) + NSAIDs => Increased risk of central nervous system arousal and seizures. -
Negative interactions
In a study involving 9 healthy volunteers, it was shown that simultaneous intravenous administration of lidocaine at a dose of 1.5 mg/kg and ciprofloxacin (500 mg 2 times a day) leads to an increase in max'>Cmax and AUC of lidocaine by 12 and 26%, respectively. Despite the good tolerability of lidocaine, when used concomitantly with ciprofloxacin, side effects may increase due to interaction. In addition, NSAIDs can mask fever, pain, swelling and other signs and symptoms of infection. Glucocorticoids (H02AB) + Amidopyrine, acetylsalicylic acid, butadione, indomethacin and other nonsteroidal anti-inflammatory drugs => Development of edema, increased damaging effect on the mucous membrane of the gastrointestinal tract. -
Positive interactions
Higher doses of lidocaine and titration may be required before clinical effect is achieved. -
Unclear interactions
Lidocaine + Dexamethasone analgin and citramon are used together in Ambene. Lidocaine. НПВС.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine