Compatibility «Valz H» and «Uperio»
Between «Valz H» and «Uperio» found 3 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Uperio |
✘Valz H [Valsartan+Hydrochlorothiazide and more 2Valsartan, Hydrochlorothiazide] Analogs | |
✘Uperio [Valsartan+Sacubitril and more 1Valsartan] Analogs |
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Interactions Valz H with Uperio
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Dangerous interactions
In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure. It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. The use of valsartan + sacubitril complex simultaneously with NSAIDs in patients over the age of 65 years, in patients with hypovolemia (including patients receiving diuretics) and patients with impaired renal function may increase the risk of deterioration of renal function. -
Negative interactions
drugs: Valz H and Uperio available common active substance : Valsartan. Pay attention to the dosage.. Other antihypertensive drugs. It may be necessary to adjust the dose of simultaneously prescribed antihypertensive drugs. In the case of additional use of diuretic drugs, the risk of toxic effects of lithium may increase. -
Unclear interactions
Valsartan + Valsartan+Sacubitril analgin and citramon are used together in Uperio, Сакубитрила и валсартана гидратный комплекс натриевых солей. Valsartan + Valsartan+Hydrochlorothiazide analgin and citramon are used together in 8 preparations. Valsartan + Hydrochlorothiazide analgin and citramon are used together in 11 preparations.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine