Compatibility «Valsacor» and «Espiro»
Between «Valsacor» and «Espiro» found 7 dangerous and 6 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Espiro |
✘Valsacor [Valsartan+Hydrochlorothiazide and more 2Valsartan, Hydrochlorothiazide] Analogs | |
✘Espiro [Eplerenone] Analogs |
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Interactions Valsacor with Espiro
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Dangerous interactions
When using iodine contrast agents in high doses against a background of reduced BCC due to the use of diuretics, there is an increased risk of acute renal failure. The simultaneous use of valsartan with other drugs that block RAAS, potassium-sparing diuretics (for example, spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium, or other drugs that can increase potassium levels (for example, heparin), may lead to an increase in serum potassium, and in patients with heart failure - to increase serum creatinine. In elderly patients, patients with dehydration (including those taking diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm valsartan, may lead to deterioration of renal function, including possible acute renal failure. Given the increased risk of hyperkalemia, eplerenone should not be prescribed to patients receiving potassium-sparing diuretics and potassium preparations (see 'Contraindications'), Potassium-sparing diuretics may enhance the effects of antihypertensive drugs and other diuretics. A triple combination of ACE inhibitor, ARA II and eplerenone should not be used. It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Hypokalemia and hypomagnesemia caused by the action of thiazide diuretics increase the toxicity of cardiac glycosides. -
Negative interactions
When used concomitantly with ACE inhibitors and diuretics, cases of reversible increases in the plasma concentration of lithium and its toxic effects have been reported. The risk of hypokalemia caused by diuretics may increase with the simultaneous use of corticosteroids, laxatives, ACTH, amphotericin B, carbenoxolone, penicillin, acetylsalicylic acid or its derivatives and antiarrhythmic drugs. The hyponatremic effect caused by diuretics may be enhanced when used concomitantly with antidepressants, antipsychotics, anticonvulsants (carbamazepine). Hypokalemia and hypomagnesemia (undesirable effects of thiazide diuretics) may contribute to the development of cardiac arrhythmias in patients receiving cardiac glycosides. ACE inhibitors and ARA II. When using eplerenone with ACE inhibitors or ARA II, the potassium content in the blood serum should be carefully monitored. -
No interactions
The simultaneous use of potassium-sparing diuretics, dietary supplements containing potassium; potassium-containing salt substitutes; other medicines that increase the potassium content in blood serum (for example, heparin) requires precautions (in pm, frequent determination of potassium content in the blood). However, cases of increased concentration and lithium intoxication have been described in patients receiving lithium preparations in combination with diuretics and ACE inhibitors.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine