Compatibility «Rumycoz» and «Exforge»

• Interactions Rumycoz with Exforge

  • Negative interactions
    • ⓘ This result was not observed in individuals who did not express CYP3A5 (n=6).
    • ⓘ However, a 3-fold increase in plasma exposure to tacrolimus was reported in a kidney transplant patient (non-CYP3A5 expressor) after starting amlodipine for the treatment of post-transplant hypertension, which led to a decrease in the dose of tacrolimus.
    • ⓘ Regardless of the status of the CYP3A5 genotype, the possibility of interaction with these drugs cannot be excluded.
    • ⓘ Inhibitors of the CYP3A4 isoenzyme.
    • ⓘ Ritonavir (a powerful inhibitor of the CYP3A4 isoenzyme) increases plasma concentrations of BMCC, in pm amlodipine.
    • ⓘ It is possible that powerful inhibitors of the CYP3A4 isoenzyme (for example, ketoconazole, itraconazole, ritonavir) may increase the concentration of amlodipine in blood plasma to a greater extent than diltiazem.
    • ⓘ Amlodipine should be used with caution simultaneously with inhibitors of the CYP3A4 isoenzyme (especially in elderly patients).
    • ⓘ Clarithromycin is an inhibitor of the CYP3A4 isoenzyme.
    • ⓘ Amlodipine should be used with caution simultaneously with inducers of the CYP3A4 isoenzyme (phenobarbital, phenytoin, carbamazepine, primidone, rifampicin, St. John's wort preparations), blood pressure should be carefully monitored with their simultaneous use (possibly weakening the antihypertensive effect of amlodipine).
    • ⓘ Since amlodipine is a weak inhibitor of CYP3A4, the exposure of mTOR inhibitors may increase when used together.
  • No interactions
    • ⓘ There is no data on the effect of inducers of the CYP3A4 isoenzyme on the pharmacokinetics of amlodipine.
  • Positive interactions
    • ⓘ A prospective study involving healthy volunteers from China (n=9), CYP3A5 expressers, showed an increase in tacrolimus exposure by 2.5-4 times when used concomitantly with amlodipine compared with the use of tacrolimus alone.
    • ⓘ Enhances and/or prolongs the effect of oral anticoagulants (in pm warfarin), cyclosporine, digoxin, methylprednisolone, vincristine, calcium channel blockers.
  • Unclear interactions
    • ⓘ However, strong CYP3A inhibitors (e.g., itraconazole, clarithromycin) can increase plasma concentrations of amlodipine to a greater extent.
    • ⓘ Inducers of the CYP3A4 isoenzyme.
    • ⓘ mTOR inhibitors (e.g. temsirolimus, sirolimus, everolimus) are substrates of CYP3A4.
    • ⓘ Calcium channel blockers.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,990,749 possible combinations of drugs and their components were found 412,526 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-11-07

Category - medicine