Compatibility «Restasis» and «Acofil»

• Interactions Restasis with Acofil

  • Dangerous interactions
    • ⓘ Increases the risk of myopathy and rhabdomyolysis when prescribing lipid-lowering drugs (HMG-CoA reductase inhibitors), impaired renal function - against the background of aminoglycosides, amphotericin B, trimethoprim, co-trimoxazole, ciprofloxacin, some cephalosporins, NSAIDs, propafenone.
    • ⓘ Cyclosporine (L04AD01) + NSAIDs — Coxibs. NSAIDs are Oxycams. NSAIDs are Phenamates. NSAIDs are Pyrazolones. NSAIDs — Butylpyrazolidines(S01BC,M01A, M01B) => Nephrotoxicity increases. (A dangerous combination, it must be avoided).
  • Negative interactions
    • ⓘ It enhances the effect of quinidine, theophylline, sodium valproate, as well as potassium preparations and potassium-sparing diuretics (the likelihood of hyperkalemia increases).
    • ⓘ Cimetidine, allopurinol, cyclosporine A, macrolide antibiotics, oral contraceptives, anti-influenza serum, a diet low in protein and high in carbohydrates - reduce clearance and increase the risk of side effects.
    • ⓘ Phenytoin, carbamazepine, barbiturates, benzodiazepine derivatives, aminoglutetimide, estrogen-progestogenic drugs, progesterone, rifampicin, isoniazid, sodium metamizole weaken the effect - accelerate elimination.
    • ⓘ with drugs with nephrotoxic effects: aminoglycosides (including gentamicin, tobramycin), amphotericin B, ciprofloxacin, mannitol, melphalan, co-trimoxazole (trimethoprim + sulfamethoxazole), vancomycin, nonsteroidal anti‑inflammatory drugs (including diclofenac, indomethacin, naproxen, sulindac), blockers H₂-histamine receptors (including cimetidine, ranitidine), methatrexate with tacrolimus, etc.
    • ⓘ Nonsteroidal anti-inflammatory drugs with a pronounced 'first pass' effect through the liver (for example, diclofenac) should be used in lower doses than in patients who do not receive cyclosporine.
    • ⓘ Reduces the concentration of cyclosporine in plasma.
    • ⓘ The combined use of metamizole with CYP2B6 and/or CYP3A4 substrates, such as bupropion and efavirenz, methadone, cyclosporine, tacrolimus or sertraline, may lead to a decrease in the concentration of these drugs in blood plasma.
    • ⓘ Therefore, caution is recommended when using metamizole and CYP2B6 and/or CYP3A4 substrates simultaneously; assessment of the clinical response and / or concentration of the drug in blood plasma should be accompanied by therapeutic drug monitoring.
  • Unclear interactions
    • ⓘ With the simultaneous use of nonsteroidal anti-inflammatory drugs with a less pronounced 'first pass' effect (for example, acetylsalicylic acid) with cyclosporine, an increase in their bioavailability is not expected.
    • ⓘ With CYP2B6 and/or CYP3A4 substrates.
    • ⓘ Metamizole can induce the metabolizing enzymes CYP2B6 and CYP3A4.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine