Compatibility «Paracetamol+Ascorbic acid+Succinic acid+Rutoside+Phenylephrine» and «Pichtanolum»

• Interactions Paracetamol+Ascorbic acid+Succinic acid+Rutoside+Phenylephrine with Pichtanolum

  • Dangerous interactions
    • ⓘ Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which leads to the possibility of severe intoxication with small overdoses.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Caution should be exercised when using paracetamol and flucloxacillin simultaneously, which is associated with an increased risk of developing metabolic acidosis with a high anionic difference, especially in patients with a risk factor for developing glutathione deficiency (in pm patients with severe renal insufficiency, sepsis, malnutrition and chronic alcoholism).
  • Negative interactions
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Ethanol contributes to the development of acute pancreatitis.
    • ⓘ Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
    • ⓘ With prolonged use or use in high doses, the disulfiram-ethanol interaction may interfere.
  • Positive interactions
    • ⓘ Paracetamol enhances the effects of MAO inhibitors, sedatives, and ethanol.
  • Unclear interactions
    • ⓘ It may affect the effectiveness of disulfiram in the treatment of chronic alcoholism.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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  • See the compatibility of drugs with alcohol (enter it as a drug).
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine