Compatibility «Metformin+Sibutramine» and «Metformin»

• Interactions Metformin+Sibutramine with Metformin

  • Dangerous interactions
    • ⓘ Treatment with metformin should be discontinued, depending on renal function, 48 hours before or during an X-ray examination using iodine-containing radiopaque agents and should not be resumed earlier than 48 hours after the examination, provided that renal function was recognized as normal during the examination.
    • ⓘ Metformin should not be prescribed if creatinine Cl is below 60 ml/min.
    • ⓘ Excessive alcohol consumption should be avoided while taking metformin.
  • Negative interactions
    • ⓘ If treatment with danazol is necessary and after discontinuation of the latter, a dose adjustment of metformin is required under the control of blood glucose concentration.
    • ⓘ In the treatment of GCS and after discontinuation of the latter, metformin dose adjustment is required under the control of blood glucose concentration.
    • ⓘ If necessary, the dose of metformin can be adjusted during and after treatment.
    • ⓘ If necessary, the dose of metformin should be adjusted.
    • ⓘ The hypoglycemic effect of metformin can be reduced by phenothiazines, glucagon, estrogens, oral contraceptives, phenytoin, sympathomimetics, nicotinic acid, isoniazid, BMCC, sodium levothyroxine.
    • ⓘ Concomitant use with cimetidine reduces the rate of metformin elimination, which can lead to the development of lactic acidosis.
    • ⓘ In healthy volunteers, no changes in their pharmacokinetic parameters were observed with the simultaneous use of metformin and propranolol, as well as with the use of metformin and ibuprofen.
    • ⓘ - OST1 inhibitors (such as verapamil) they can reduce the hypoglycemic effect of metformin;.
    • ⓘ - OST1 inducers (such as rifampicin) can increase the absorption of metformin in the gastrointestinal tract and enhance its hypoglycemic effect;.
    • ⓘ - OST2 inhibitors (such as cimetidine, dolutegravir, ranolazine, trimethoprim, vandetanib, isavuconazole) can reduce the excretion of metformin by the kidneys and lead to an increase in its concentration in blood plasma.
    • ⓘ OST1 and OST2 inhibitors (such as crizotinib, olaparide) can reduce the hypoglycemic effect of metformin.
    • ⓘ With the simultaneous use of metformin with sulfonylurea derivatives, insulin, acarbose, salicylates, hypoglycemia may develop.
    • ⓘ Nifedipine increases the absorption and max'>C_max of metformin.
    • ⓘ Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin) secreted in the renal tubules compete with metformin for tubular transport systems and can lead to an increase in its max'>C_max.
    • ⓘ The following are clinically significant interactions of metformin with other drugs.
    • ⓘ The simultaneous use of these drugs and metformin may increase the risk of developing lactate acidosis.
    • ⓘ Concomitant use of drugs affecting the renal tubular transport system involved in the elimination of metformin (for example, OCT2 and MATE inhibitors) may increase systemic exposure to metformin and the risk of lactate acidosis.
    • ⓘ The risk/benefit ratio of the combined use of such drugs with metformin should be carefully evaluated.
    • ⓘ The combined use of metformin and insulin secretion stimulants (e.g. sulfonylurea) or insulin may increase the risk of hypoglycemia.
    • ⓘ The simultaneous use of these drugs and metformin can cause hyperglycemia and lead to loss of glycemic control.
    • ⓘ Discontinuation of such drugs in patients receiving metformin requires careful monitoring of their condition due to the possibility of hypoglycemia.
    • ⓘ Alcohol potentiates the effect of metformin on lactate metabolism.
    • ⓘ Drugs: Metformin+Sibutramine and Metformin there is common active substance : Metformin. Pay attention to the dosage..
  • No interactions
    • ⓘ When used in combination with metformin:.
    • ⓘ The combined use of such drugs and metformin requires careful monitoring of blood glucose levels in patients.
  • Unclear interactions
    • ⓘ Metformin.
    • ⓘ Metformin may reduce the effect of indirect anticoagulants.
    • ⓘ Metformin is a substrate of the organic cations OST1 and OST2.
    • ⓘ Drugs that reduce the clearance of metformin (ranolazine, vandetanib, dolutegravir and cimetidine).
    • ⓘ Metformin + Metformin hydrochloride analgin and citramon are used together in 12 preparations.
    • ⓘ Metformin + Metformin+Sibutramine analgin and citramon are used together in Reduxin Forte.
    • ⓘ Metformin + Sibutramine analgin and citramon are used together in Reduxin Met, Reduxin Forte, Голдлайн КОМБИ.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine