Compatibility «Amlodipine+Bisoprolol» and «Amiodarone»

• Interactions Amlodipine+Bisoprolol with Amiodarone

  • Dangerous interactions
    • ⓘ Regardless of the status of the CYP3A5 genotype, the possibility of interaction with these drugs cannot be excluded.
    • ⓘ Calcium channel blockers(C08) + Class III Antiarrhythmic drugs (C01BD) => Danger of cardiac arrest. (The combination is unacceptable).
    • ⓘ Calcium channel blockers (C08,C08CA) + Class I and III antiarrhythmic drugs (C01B) => Significantly increases the likelihood of ventricular fibrillation. (The combination should be avoided).
    • ⓘ Incompatible with BCC (increases the likelihood of AV blockage and hypotension).
    • ⓘ Simultaneous use with drugs that have a depressing effect on the sinus node and slow down atrioventricular conduction (for example, digoxin, beta‑blockers, blockers of 'slow' calcium channels, reducing heart rate [verapamil, diltiazem], ivabradine) can enhance the electrophysiological and hemodynamic effects of amiodarone and lead to severe bradycardia, sinus node arrest and atrioventricular block.
    • ⓘ Class I antiarrhythmic agents (for example, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone), when used simultaneously with bisoprolol, can reduce AV conduction and contractility of the heart.
    • ⓘ Class I antiarrhythmic agents (for example, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone), when used simultaneously with bisoprolol, can reduce AV conduction and myocardial contractility.
    • ⓘ Class III antiarrhythmic agents (for example, amiodarone) can enhance the violation of AV conduction.
  • Negative interactions
    • ⓘ However, a 3-fold increase in plasma exposure to tacrolimus was reported in a kidney transplant patient (non-CYP3A5 expressor) after starting amlodipine for the treatment of post-transplant hypertension, which led to a decrease in the dose of tacrolimus.
    • ⓘ Inhibitors of the CYP3A4 isoenzyme.
    • ⓘ Although no negative inotropic effect was usually observed in the study of amlodipine, nevertheless, some BMCC may enhance the severity of the negative inotropic effect of antiarrhythmic agents that cause prolongation of the QT interval (for example, amiodarone and quinidine).
    • ⓘ The probability of violations of automatism, conduction and contractility of the heart increases (mutually) against the background of amiodarone, diltiazem, verapamil, quinidine preparations, cardiac glycosides, reserpine, alpha-methyldopha.
    • ⓘ Beta-blockers increase the risk of hypotension and bradycardia.
  • No interactions
    • ⓘ Since amlodipine is a weak inhibitor of CYP3A4, the exposure of mTOR inhibitors may increase when used together.
  • Positive interactions
    • ⓘ A prospective study involving healthy volunteers from China (n=9), CYP3A5 expressers, showed an increase in tacrolimus exposure by 2.5-4 times when used concomitantly with amlodipine compared with the use of tacrolimus alone.
  • Unclear interactions
    • ⓘ This result was not observed in individuals who did not express CYP3A5 (n=6).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine