Compatibility «Ibuprofen+Paracetamol» and «Diclofenac»

• Interactions Ibuprofen+Paracetamol with Diclofenac

  • Dangerous interactions
    • ⓘ Ibuprofen (like other NSAIDs) should be used with caution in combination with acetylsalicylic acid or other NSAIDs and GCS due to an increased risk of adverse effects of this drug on the gastrointestinal tract.
    • ⓘ Diclofenac, like other NSAIDs, can affect the synthesis of renal PH and increase the toxicity of some drugs.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
  • Negative interactions
    • ⓘ Like other NSAIDs, ibuprofen, when used concomitantly with cardiac glycosides, can lead to an increase in the content of cardiac glycosides.
    • ⓘ With the simultaneous use of ibuprofen (as well as other NSAIDs) and tacrolimus, the risk of nephrotoxicity of ibuprofen increases.
    • ⓘ Concomitant use with other NSAIDs, in particular selective COX-2 inhibitors, should be avoided due to the possible additive effect (see 'Special instructions').
    • ⓘ As with the use of other drugs containing NSAIDs, the simultaneous use of ibuprofen and acetylsalicylic acid is not recommended due to a possible increase in the likelihood of undesirable effects.
    • ⓘ Ibuprofen and Diclofenac belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ Ibuprofen and Diclofenac belong to the same pharmaceutical group: NSAIDs for topical use.
    • ⓘ The clinical significance of this interaction is unknown, however, as with other NSAIDs, concomitant administration of diclofenac and acetylsalicylic acid is usually not recommended due to the possibility of increased side effects.
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Paracetamol and Diclofenac belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
  • Unclear interactions
    • ⓘ Paracetamol + Diclofenac analgin and citramon are used together in Dolaren, Panoxen.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine