Compatibility «Acetylsalicylic acid» and «Paracetamol+Pheniramine+Ascorbic acid»

• Interactions Acetylsalicylic acid with Paracetamol+Pheniramine+Ascorbic acid

  • Dangerous interactions
    • ⓘ Taking simultaneously with salicylates increases the risk of nephrotoxic effects.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Prolonged co-use of paracetamol and other NSAIDs increases the risk of analgesic nephropathy and renal failure.
  • Negative interactions
    • ⓘ Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (in pm alkaloids), reduces the concentration of oral contraceptives in the blood.
    • ⓘ Quinoline drugs, calcium chloride, salicylates, GCS-drugs with prolonged use deplete the reserves of ascorbic acid.
    • ⓘ Acetylsalicylic acid and Paracetamol belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
    • ⓘ Salicylates (N02BA) + Ammonium chloride, calcium chloride and other drugs that increase urine acidity => Increased action of salicylates up to the development of salicylism phenomena (the appearance of tinnitus, hearing loss).
    • ⓘ Increases the concentration of salicylates in the blood (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracyclines, reduces oral contraceptives.
    • ⓘ Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce absorption and assimilation.
    • ⓘ Quinoline preparations, calcium chloride, salicylates, corticosteroids deplete vitamin C reserves with prolonged use.
    • ⓘ Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce the absorption and assimilation of ascorbic acid.
    • ⓘ Ascorbic acid increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.
    • ⓘ Quinoline preparations, calcium chloride, salicylates, glucocorticosteroids deplete ascorbic acid reserves with prolonged use.
  • Unclear interactions
    • ⓘ Acetylsalicylic acid + Paracetamol analgin and citramon are used together in 22 preparations.
    • ⓘ Acetylsalicylic acid + Ascorbic acid analgin and citramon are used together in 12 preparations.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine