Compatibility «Acetylsalicylic acid» and «Prednisolone»

• Interactions Acetylsalicylic acid with Prednisolone

  • Dangerous interactions
    • ⓘ NSAIDs, acetylsalicylic acid, and alcohol increase the risk of peptic ulcer disease and gastrointestinal bleeding.
    • ⓘ and nonsteroidal anti-inflammatory drugs (NSAIDs) - the risk of erosive and ulcerative lesions of the gastrointestinal tract and the development of bleeding increases (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect);.
  • Negative interactions
    • ⓘ A decrease in the level of salicylates in the blood during treatment with GCS.
    • ⓘ The risk of overdose of salicylates after their combined use with GCS is reduced by increasing the excretion of salicylates by corticosteroids.
    • ⓘ Salicylates (N02BA) + Amidopyrine, butadione, glucocorticoids, indomethacin => Increased damaging effect of salicylates on the mucous membrane of the stomach and duodenum (ulceration).
    • ⓘ acetylsalicylic acid - accelerates its excretion and reduces the concentration in the blood (with the abolition of prednisone, the concentration of salicylates in the blood increases and the risk of side effects increases);.
    • ⓘ Glucocorticoids (H02AB) + Amidopyrine, acetylsalicylic acid, butadione, indomethacin and other nonsteroidal anti-inflammatory drugs => Development of edema, increased damaging effect on the mucous membrane of the gastrointestinal tract.
  • Positive interactions
    • ⓘ Glucocorticoids, ethanol and ethanol-containing drugs enhance the negative effect on the gastrointestinal mucosa and increase clearance.
  • Unclear interactions
    • ⓘ System GCS,.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine