Compatibility «Acetylsalicylic acid» and «Ibuprofen+Pitofenone+Fenpiverinium bromide»

• Interactions Acetylsalicylic acid with Ibuprofen+Pitofenone+Fenpiverinium bromide

  • Dangerous interactions
    • ⓘ It enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).
    • ⓘ With simultaneous administration, the combination of ibuprofen + pitofenone + fenpiverinium bromide reduces the anti-inflammatory and antiplatelet effects of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after the start of this combination).
    • ⓘ The use of ibuprofen in patients with an increased risk of developing cardiovascular diseases may limit the cardioprotective effect of acetylsalicylic acid.
    • ⓘ With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effects of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen).
  • Negative interactions
    • ⓘ Concomitant use of ibuprofen prevents irreversible platelet inhibition caused by acetylsalicylic acid.
    • ⓘ Concomitant use with other NSAIDs, in particular selective COX-2 inhibitors, should be avoided due to the possible additive effect (see 'Special instructions').
    • ⓘ As with the use of other drugs containing NSAIDs, the simultaneous use of ibuprofen and acetylsalicylic acid is not recommended due to a possible increase in the likelihood of undesirable effects.
    • ⓘ Experimental data show that, when used together, ibuprofen can competitively inhibit the effect of low doses of acetylsalicylic acid on platelet aggregation.
    • ⓘ Despite the ambiguity in extrapolating these data to the clinical situation, the possibility that regular long-term use of ibuprofen may reduce the cardioprotective effect of low doses of acetylsalicylic acid cannot be excluded.
    • ⓘ Due to the antiprostaglandin properties of NSAIDs, in pm acetylsalicylic acid, it is theoretically possible to reduce the effectiveness of the drug.
    • ⓘ Ibuprofen and Acetylsalicylic acid belong to the same pharmaceutical group: Non-narcotic analgesics, including nonsteroidal and other anti-inflammatory drugs.
  • Positive interactions
    • ⓘ Ibuprofen enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.
  • Unclear interactions
    • ⓘ Ibuprofen.
    • ⓘ Antiplatelet agents and SSRIs (for example, clopidogrel, ticlopidine).
    • ⓘ Acetylsalicylic acid.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine