Compatibility «Captopril» and «Acetylsalicylic acid+Caffeine+Paracetamol»

• Interactions Captopril with Acetylsalicylic acid+Caffeine+Paracetamol

  • Dangerous interactions
    • ⓘ In the elderly, patients with hypovolemia (in pm receiving diuretics) or impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including captopril, may lead to deterioration of renal function, including the possible development of acute renal failure.
    • ⓘ In patients with risk factors (elderly age, hypovolemia, concomitant use of diuretics, impaired renal function), concomitant use of nonsteroidal anti-inflammatory drugs (including cyclooxygenase inhibitors‑2) and ACE inhibitors (including captopril), can lead to deterioration of renal function, up to acute renal failure.
    • ⓘ The use of captopril in combination with acetylsalicylic acid as an antiplatelet agent is not contraindicated.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
  • Negative interactions
    • ⓘ It is necessary to periodically monitor kidney function in patients receiving both captopril and NSAIDs.
    • ⓘ The antihypertensive effect of ACE inhibitors, including captopril, may decrease under the action of NSAIDs.
    • ⓘ NSAIDs, including selective cyclooxygenase‑2 (COX‑2) inhibitors and acetylsalicylic acid in doses of 3 g/day and above, can reduce the antihypertensive effect of diuretics and other antihypertensive agents.
    • ⓘ With the combined use of captopril and indomethacin (and possibly other nonsteroidal anti-inflammatory drugs, for example, acetylsalicylic acid), there may be a decrease in antihypertensive effect, especially in hypertension, accompanied by low renin activity.
    • ⓘ Kidney function should be periodically monitored in patients taking captopril and nonsteroidal anti-inflammatory drugs.
    • ⓘ Increases the toxicity of methotrexate, reducing its renal clearance, the effects of narcotic analgesics (codeine), oral antidiabetic drugs, heparin, indirect anticoagulants, thrombolytics and inhibitors of platelet aggregation, reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), hypotensive agents, diuretics (spironolactone, furosemide).
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
  • Positive interactions
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase‑2 (COX‑2) inhibitors and high doses of acetylsalicylic acid (≥3 g/day).
    • ⓘ ACE inhibitors in combination with acetylsalicylic acid in higher doses.
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine