Compatibility «Losartan+Hydrochlorothiazide» and «Indapamide»
Between «Losartan+Hydrochlorothiazide» and «Indapamide» found 8 dangerous and 23 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Indapamide |
✘Losartan+Hydrochlorothiazide [Losartan and more 1Hydrochlorothiazide] Analogs | |
✘Indapamide [Losartan and more 1Hydrochlorothiazide] Analogs |
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Interactions Losartan+Hydrochlorothiazide with Indapamide
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Dangerous interactions
In elderly patients with a decrease in the volume of intercellular fluid (including those receiving diuretics) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II (including losartan) may lead to deterioration of renal function, including the possible development of acute renal failure. The simultaneous use of ARA II or diuretics and NSAIDs may cause an increased risk of deterioration of renal function, in pm acute renal failure and increased potassium content in blood plasma, especially in patients with initial renal impairment. Diuretics reduce the renal clearance of lithium and significantly increase the risk of its toxic effects. Hypokalemia or hypomagnesemia caused by thiazide diuretics may contribute to the development of arrhythmias induced by cardiac glycosides. In the case of dehydration caused by the use of diuretics, the risk of acute renal failure increases, especially when taking high doses of iodine preparations. It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Hypokalemia and hypomagnesemia caused by the action of thiazide diuretics increase the toxicity of cardiac glycosides. Indapamide (C03BA11) + Thiazide diuretics (C03A) => Increases the likelihood of hypokalemia. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown)The likelihood of hypokalemia increases. The effect of thiazide diuretics is enhanced. (Dangerous combinations, careful correction of the K+ content in the blood is shown). -
Negative interactions
When taken simultaneously with thiazide diuretics, interaction with the following drugs may be observed. Other antihypertensive agents. Concomitant use with thiazides may increase the incidence of hypersensitivity reactions to allopurinol. It is possible to increase the bioavailability of thiazide diuretics by reducing gastrointestinal motility and the rate of gastric emptying. Thiazide diuretics can inhibit the excretion of cytotoxic drugs through the kidneys and enhance their myelosuppressive effect. Thiazide diuretics can increase the calcium content in blood plasma by reducing the excretion of calcium by the kidneys. The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs. In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy. Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted. Thiazides can reduce plasma levels of iodine bound to proteins. Thiazides should be discontinued before parathyroid function tests are performed. Other antihypertensive drugs. It may be necessary to adjust the dose of simultaneously prescribed antihypertensive drugs. Thiazide diuretics affect glucose tolerance (hyperglycemia may develop) and reduce the effectiveness of hypoglycemic agents (dose adjustment of hypoglycemic agents may be required). Concomitant use of thiazide diuretics (including hydrochlorothiazide), with beta‑blockers or diazoxide may increase the risk of hyperglycemia. It may be necessary to adjust the dose of uricosuric drugs, since hydrochlorothiazide increases the concentration of uric acid in the blood serum. Thiazide diuretics may increase the frequency of hypersensitivity reactions to allopurinol. Thiazide diuretics (including hydrochlorothiazide) can reduce the clearance of amantadine, lead to an increase in the concentration of amantadine in blood plasma and increase the risk of its undesirable effects. Anticholinergic drugs (for example, atropine, biperiden) increase the bioavailability of thiazide diuretics by reducing the motility of the gastrointestinal tract and the rate of gastric emptying. Thiazide diuretics reduce the renal excretion of cytotoxic drugs (e.g. cyclophosphamide and methotrexate) and potentiate their myelosuppressive effect. With the simultaneous use of thiazide diuretics and cyclosporine, the risk of hyperuricemia and exacerbation of gout increases. Thiazide diuretics may reduce the effect of oral anticoagulants. Dehydration of the body while taking thiazide diuretics increases the risk. Indapamide and Hydrochlorothiazide belong to the same pharmaceutical group: Thiazide diuretics. -
Positive interactions
When used concomitantly with thiazide diuretics, hyponatremia may be potentiated. -
Unclear interactions
Treatment with thiazide diuretics may affect glucose tolerance. Due to the effect on calcium metabolism, thiazides can distort the results of tests to assess the function of the parathyroid glands.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,978,048 possible combinations of drugs and their components were found 412,514 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-06-13
Category - medicine