Compatibility «Amoxicillin+Clavulanic acid» and «Methotrexate»

• Interactions Amoxicillin+Clavulanic acid with Methotrexate

  • Dangerous interactions
    • ⓘ Penicillins (J01CA) + Methotrexate => Increased toxic effects of methotrexate.
    • ⓘ Other drugs that cause inhibition of bone marrow function or radiation therapy potentiate the effect and additively inhibit bone marrow function.
    • ⓘ Methotrexate partially binds to serum albumin and can be displaced from this connection when used simultaneously with drugs that strongly bind to plasma proteins, such as sulfonylureas, aminobenzoic acid, salicylates, phenylbutazone, phenytoin, sulfonamides, some antibiotics (penicillins, tetracycline, pristinamycin, chloramphenicol), probenecid, which can lead to an increase in toxicity of methotrexate.
    • ⓘ The possibility of increased hepatotoxicity when prescribing methotrexate with other hepatotoxic drugs has not been evaluated.
    • ⓘ Therefore, patients receiving methotrexate and other potentially hepatotoxic drugs together (for example, leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored due to a possible increased risk of hepatotoxicity.
  • Negative interactions
    • ⓘ Penicillins can reduce the excretion of methotrexate, causing a possible increase in toxicity.
    • ⓘ Penicillins and sulfonamides can reduce the renal clearance of methotrexate, hematological and gastrointestinal toxicity has been observed in combination with methotrexate.
    • ⓘ The concomitant use of methotrexate with penicillins should be carefully monitored.
  • Unclear interactions
    • ⓘ Methotrexate.
    • ⓘ Penicillin group drugs reduce the renal clearance of methotrexate.
    • ⓘ Penicillins and sulfonamides.
    • ⓘ Hepatotoxic drugs.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine