Compatibility «Escitalopram» and «Amiodarone»

• Interactions Escitalopram with Amiodarone

  • Negative interactions
    • ⓘ Although in vivo data are limited to answer this question, the results of drug interaction studies show that escitalopram at a dose of 20 mg does not have an inhibitory effect on CYP3A4 and has a moderate inhibitory effect on CYP2D6.
  • No interactions
    • ⓘ The use of the racemic form of citalopram at a dose of 40 mg/ day for 21 days did not affect the pharmacokinetics of warfarin, a CYP3A4 substrate.
    • ⓘ The combined intake of the racemic form of citalopram (40 mg / day for 14 days) and carbamazepine (titrated dose up to 400 mg / day for 35 days) had no significant effect on the pharmacokinetics of carbamazepine, a CYP3A4 substrate.
    • ⓘ The combined use of the racemic form of citalopram (titrated to 40 mg/ day for 28 days) and the CYP3A4 substrate triazolam (a single dose of 0.25 mg) had no significant effect on the pharmacokinetics of citalopram or triazolam.
    • ⓘ The combined use of a single dose of ritonavir (600 mg), both a CYP3A4 substrate and a strong CYP3A4 inhibitor, and escitalopram (20 mg) did not affect the pharmacokinetics of ritonavir or escitalopram.
    • ⓘ However, concomitant administration of escitalopram (20 mg) and ritonavir (600 mg), a strong CYP3A4 inhibitor, had no significant effect on the pharmacokinetics of escitalopram.
  • Unclear interactions
    • ⓘ Data on in vitro inhibition of isoenzymes'>in vitro did not reveal an inhibitory effect of escitalopram on CYP3A4, CYP1A2, CYP2C9, CYP2C19 and CYP2E1.
    • ⓘ Inhibitors of CYP3A4 and CYP2C19.
    • ⓘ In vitro studies have shown that CYP3A4 and CYP2C19 are the main isoenzymes involved in the metabolism of escitalopram.
    • ⓘ Antidepressants:.
    • ⓘ tricyclic antidepressants, selective serotonin reuptake inhibitors.
    • ⓘ (citalopram, escitalopram);.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine