Compatibility «Rabeprazole» and «Clarithromycin+Lansoprazole+Amoxicillin»

• Interactions Rabeprazole with Clarithromycin+Lansoprazole+Amoxicillin

  • Dangerous interactions
    • ⓘ Thus, lansoprazole and other proton pump inhibitors should not be used in conjunction with atazanavir.
  • Negative interactions
    • ⓘ Concentrations of rabeprazole and the active metabolite clarithromycin in plasma increase by 24 and 50%, respectively, when taken simultaneously.
    • ⓘ In vitro studies on human liver microsomes have shown that rabeprazole sodium is metabolized by CYP2C19 and CYP3A4 isoenzymes.
    • ⓘ The AUC and max values'>C_max for rabeprazole increased by 11% and 34%, respectively, and for 14‑hydroxy-clarithromycin (the active metabolite of clarithromycin) AUC and C_max.
    • ⓘ However, there have been reports of increased INR and prothrombin time in patients who were simultaneously taking proton pump inhibitors and warfarin.
    • ⓘ When atazanavir 300 mg / ritonavir 100 mg was co-administered with omeprazole (40 mg 1 time per day) or atazanavir 400 mg with lansoprazole (60 mg 1 time per day) in healthy volunteers, there was a significant decrease in the effects of atazanavir.
    • ⓘ Lansoprazole and Rabeprazole belong to the same pharmaceutical group: Proton Pump Inhibitors.
    • ⓘ Studies in healthy volunteers have shown that rabeprazole does not enter into a clinically significant interaction with amoxicillin and other drugs that are metabolized by this enzyme system (warfarin, phenytoin, theophylline, diazepam).
  • No interactions
    • ⓘ It was found that rabeprazole has neither a stimulating nor an inhibitory effect on CYP3A4 at the expected plasma concentrations.
    • ⓘ This increase in exposure rates for rabeprazole and clarithromycin was not considered clinically significant.
  • Unclear interactions
    • ⓘ This four-way cross-sectional study involved 16 healthy volunteers who received 20 mg of rabeprazole, 1000 mg of amoxicillin, 500 mg of clarithromycin or a combination of these three drugs (CANCER - rabeprazole, amoxicillin, clarithromycin).
    • ⓘ The AUC and max'>C_max values for clarithromycin and amoxicillin were similar when comparing combination therapy with monotherapy.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine