Compatibility «Warfarin» and «Amoxicillin+Clavulanic acid»

• Interactions Warfarin with Amoxicillin+Clavulanic acid

  • Dangerous interactions
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics¹ (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants¹, antidepressants¹, intravaginal and systemic antifungal drugs¹, antimalarial drugs, antitumor drugs¹, antiparasitic and antimicrobial drugs¹, platelet aggregation inhibitors, antiteroid drugs¹, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics¹, drugs that regulate the acidity of gastric juice and anti-ulcer drugs¹, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs¹, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)¹, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins¹.
    • ⓘ Penicillins (J01CA) + Anticoagulants (direct and indirect), thrombolytics, NSAIDs, salicylates => Increased risk of bleeding (especially with high doses of carbenicillin, ureidopenicillins).
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: steroid inhibitors of the adrenal cortex, antacids, sedatives, antiarrhythmic drugs¹, antibiotics¹, anticonvulsants¹, antidepressants¹, antifungal drugs of systemic action¹, antihistamines, antitumor drugs¹, neuroleptics, antireoid agents¹, barbiturates, diuretics¹, enteral dietary supplements , enzyme inhibitors, drugs for the regulation of gastric acidity and treatment of peptic ulcer¹, hypnotic drugs¹, immunosuppressants, lipid-lowering drugs (bile acid sequestrants, HMG-CoA reductase inhibitors)¹, drugs of natural origin, oral contraceptives, selective estrogen receptor modulators, adrenocorticosteroids, anti-tuberculosis drugs¹, vitamins¹.
  • Negative interactions
    • ⓘ To maintain the desired level of anticoagulation, it may be necessary to adjust the dose of oral anticoagulants.
    • ⓘ However, there are rare reports in the literature of an abnormal increase in INR in patients treated with acenocumarol or warfarin when prescribing a course of treatment with amoxicillin.
    • ⓘ In addition, it may be necessary to adjust the dose of oral anticoagulants.
    • ⓘ To maintain the required level of anticoagulation, it may be necessary to adjust the dose of oral anticoagulants.
  • No interactions
    • ⓘ Oral anticoagulants and penicillin antibiotics are widely used in practice, there are no reports of interaction.
  • Unclear interactions
    • ⓘ Oral anticoagulants.
    • ⓘ Abnormal prolongation of PV (increased INR) has been reported in patients treated with amoxicillin and oral anticoagulants.
    • ⓘ When prescribing anticoagulants with a combination of amoxicillin + clavulanic acid, appropriate monitoring should be carried out.
    • ⓘ Abnormal prolongation of PV (increase in INR) has been reported in patients taking amoxicillin and oral anticoagulants.
    • ⓘ When prescribing anticoagulants at the same time, appropriate monitoring should be carried out.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine