Compatibility «Citalopram» and «Clotrimazole»

• Interactions Citalopram with Clotrimazole

  • Negative interactions
    • ⓘ In vitro isoenzyme inhibition data have not revealed the inhibitory effect of citalopram on CYP3A4, CYP2C9 or CYP2E1, but suggest that it is a weak inhibitor of CYP1A2, CYP2D6 and CYP2C19.
    • ⓘ Since CYP3A4 and CYP2C19 are the main isoenzymes involved in citalopram metabolism, it is expected that strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole and macrolides) and strong CYP2C19 inhibitors (e.g. omeprazole) may reduce citalopram clearance.
  • No interactions
    • ⓘ However, concomitant administration of citalopram and the strong CYP3A4 inhibitor ketoconazole had no significant effect on the pharmacokinetics of citalopram.
    • ⓘ The use of citalopram at a dose of 40 mg / day for 21 days did not affect the pharmacokinetics of warfarin, a CYP3A4 substrate.
    • ⓘ Combined administration of citalopram (40 mg / day for 14 days) and carbamazepine (titrated dose up to 400 mg / day for 35 days) had no significant effect on the pharmacokinetics of carbamazepine, a CYP3A4 substrate.
    • ⓘ The combined use of citalopram (titrated to 40 mg/day for 28 days) and the CYP3A4 substrate triazolam (a single dose of 0.25 mg) had no significant effect on the pharmacokinetics of citalopram or triazolam.
  • Unclear interactions
    • ⓘ Inhibitors of CYP3A4 and CYP2C19.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine