Compatibility «Betamethasone» and «Prednisolone»
Between «Betamethasone» and «Prednisolone» found 10 dangerous and 15 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Prednisolone |
✘Betamethasone Analogs | |
✘Prednisolone Analogs |
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Interactions Betamethasone with Prednisolone
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Dangerous interactions
Therapeutic, toxic effects are reduced by inducers of liver enzymes, enhanced by estrogens and oral contraceptives, the likelihood of arrhythmias and hypokalemia is increased by digitalis glycosides, diuretics (causing potassium deficiency), amphotericin B, carbonic anhydrase inhibitors; the risk of ulcerative erosive lesions or bleeding in the gastrointestinal tract - alcohol and NSAIDs. With the simultaneous use of GCS and estrogens, it may be necessary to adjust the dose of drugs (due to the danger of overdose). Concomitant use with strong CYP3A4 inhibitors (for example, ketoconazole, itraconazole, clarithromycin, ritonavir, drugs containing cobicistat) may lead to an increase in corticosteroid exposure and, consequently, to an increase in the potential risk of systemic HP during GCS therapy. Concomitant use of betamethasone and strong CYP3A4 inhibitors should be avoided if the expected benefit of GCS therapy does not exceed the risk of systemic HP. The simultaneous use of GCS and cardiac glycosides increases the risk of arrhythmia or digitalis intoxication (due to hypokalemia). Simultaneous administration of GCS and somatropin may lead to a slowdown in the absorption of the latter (doses of betamethasone exceeding 0.3-0.45 mg/m 2 body surface per day should be avoided). GCS can reduce the effect of cholinesterase inhibitors, which can lead to the development of severe muscle weakness in patients with myasthenia gravis. During the use of immunosuppressive doses of glucocorticoids and vaccines containing live viruses, virus replication and the development of viral diseases are possible, and antibody production is reduced (simultaneous use is not recommended). and nonsteroidal anti-inflammatory drugs (NSAIDs) - the risk of erosive and ulcerative lesions of the gastrointestinal tract and the development of bleeding increases (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of GCS due to the summation of the therapeutic effect);. tricyclic antidepressants - may increase the severity of depression caused by taking GCS (not indicated for the treatment of these side effects);. -
Negative interactions
With the simultaneous administration of phenobarbital, rifampicin, phenytoin or ephedrine, it is possible to accelerate the metabolism of corticosteroid with a decrease in its therapeutic activity. With the combined use of GCS and potassium-releasing diuretics, the likelihood of hypokalemia increases. With the combined use of GCS with NSAIDs or ethanol, it is possible to increase the frequency or intensity of erosive and ulcerative lesions of the gastrointestinal tract. When used together, GCS can reduce the concentration of salicylates in blood plasma. GCS can affect the nitrogen blue tetrazole test for bacterial infection and cause a false negative result. Aminoglutetimide may cause increased or decreased suppression of adrenal cortex function caused by corticosteroids. With the simultaneous use of GCS and ketoconazole or itraconazole, it is possible to increase the systemic side effects of GCS. If possible, cholinesterase inhibitors should be discontinued at least 24 hours before the start of GCS therapy. With the simultaneous use of GCS and isoniazid, it is possible to reduce the concentration of isoniazid in blood plasma. The simultaneous use of cyclosporine and GCS can lead to an increase in the concentration of cyclosporine in the systemic bloodstream and an increase in the action of GCS. With the simultaneous use of GCS with antibiotics of the macrolide group, a significant decrease in the excretion of GCS is possible. When used simultaneously with colesteramine, it is possible to increase the excretion of GCS. Betamethasone and Prednisolone belong to the same pharmaceutical group: Glucocorticosteroids. Barbiturates, antiepileptic drugs (phenytoin, carbamazepine), rifampicin accelerate the metabolism of glucocorticoids (by induction of microsomal enzymes). Hypokalemia caused by GCS can increase the severity and duration of muscle block against the background of muscle relaxants. -
Unclear interactions
GCS (including betamethasone) are metabolized by the enzyme CYP3A4.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,976,234 possible combinations of drugs and their components were found 412,512 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-23
Category - medicine