Compatibility «Tenoxicam» and «Hydrochlorothiazide+Telmisartan»

• Interactions Tenoxicam with Hydrochlorothiazide+Telmisartan

  • Dangerous interactions
    • ⓘ In elderly patients, patients with dehydration (including those taking diuretics) or impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ARA II, in pm telmisartan, may lead to deterioration of renal function, including possible acute renal failure.
    • ⓘ This should be remembered when used in combination with such diuretics in patients with CHF and hypertension.
    • ⓘ It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension.
    • ⓘ In elderly people with reduced BCC (including those receiving diuretic therapy) or with impaired renal function, the combined use of NSAIDs, in pm, selective COX-2 inhibitors with ARA II, including telmisartan, may lead to deterioration of renal function, including possible acute renal failure.
  • Negative interactions
    • ⓘ The use of NSAIDs, including selective COX-2 inhibitors, can reduce the diuretic, natriuretic and antihypertensive effects of diuretics.
    • ⓘ Therefore, when using a combination of hydrochlorothiazide + telmisartan and NSAIDs, including selective COX-2 inhibitors, it is necessary to carefully monitor to determine whether the desired effect of the diuretic is achieved.
    • ⓘ The antihypertensive effect of ARA II can be weakened by NSAIDs.
    • ⓘ Renal function and blood pressure should be periodically monitored in patients receiving a combination of hydrochlorothiazide + telmisartan and NSAIDs.
    • ⓘ NSAIDs can reduce the diuretic and antihypertensive effects of hydrochlorothiazide.
    • ⓘ The risk of hyperkalemia may increase when used concomitantly with other drugs that can cause hyperkalemia (potassium-containing dietary supplements and salt substitutes containing potassium, potassium-sparing diuretics, for example, spironolactone, eplerenone, triamterene or amiloride), NSAIDs, including selective COX-2 inhibitors, heparin, immunosuppressants (cyclosporine or tacrolimus) and trimethoprim.
    • ⓘ The use of telmisartan in combination with ACE inhibitors or NSAIDs poses a lower risk, provided that precautions are strictly followed.
    • ⓘ NSAIDs (td; acetylsalicylic acid in doses used for anti-inflammatory treatment, COX-2 inhibitors and non-selective NSAIDs) may weaken the antihypertensive effect of ARA II.
    • ⓘ NSAIDs can cause sodium, potassium and fluid retention in the body, disrupting the action of natriuretic diuretics.
    • ⓘ Reduces the effectiveness of antihypertensive drugs and diuretics.
    • ⓘ Kidney function should be monitored periodically in patients receiving telmisartan and NSAIDs.
    • ⓘ The antihypertensive effect of ARA II, including telmisartan, can be weakened by NSAIDs, including selective COX-2 inhibitors.
    • ⓘ The risk may increase when combined with other medications that can also provoke hyperkalemia (salt substitutes containing potassium, potassium‑sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, nonsteroidal anti‑inflammatory drugs (NSAIDs, including selective COX-2 inhibitors), heparin, immunosuppressants (cyclosporine or tacrolimus) and co-trimoxazole (trimethoprim + sulfamethoxazole).
    • ⓘ Concomitant use with ACE inhibitors or NSAIDs, including selective COX‑2 inhibitors, is accompanied by a lower risk of hyperkalemia, provided careful observance of precautions.
    • ⓘ Nonsteroidal anti‑inflammatory drugs NSAIDs (for example, acetylsalicylic acid in anti-inflammatory dosage regimens, COX-2 inhibitors and non-selective NSAIDs) can reduce the antihypertensive effect of angiotensin II receptor antagonists.
  • Positive interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors and high doses of acetylsalicylic acid (>3 g /day).
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors and high doses of acetylsalicylic acid (≥3 g/day).
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ НПВП.
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine