Compatibility «Ketoconazole» and «Clotrimazole»
Between «Ketoconazole» and «Clotrimazole» found 1 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Clotrimazole |
| ✘Ketoconazole Analogs | |
| ✘Clotrimazole Analogs |
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Interactions Ketoconazole with Clotrimazole
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Dangerous interactions
- With the simultaneous use of ketoconazole with powerful inducers of the CYP3A4 isoenzyme, it is possible to reduce the bioavailability of ketoconazole, which can cause a significant decrease in its effectiveness.
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Negative interactions
- With the simultaneous use of ketoconazole with powerful inhibitors of the CYP3A4 isoenzyme (for example, antiviral drugs, including ritonavir, ritonavir-enhanced darunavir and ritonavir-enhanced fosamprenavir), the bioavailability of ketoconazole may increase.
- Ketoconazole and Clotrimazole belong to the same pharmaceutical group: Antifungal agents.
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Unclear interactions
- With simultaneous use, ketoconazole is able to inhibit CYP3A4-mediated drug metabolism, as well as the transport of active substances due to P-glycoprotein.
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Dangerous interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2026-01-01
Category - medicine