Compatibility «Ibuprofen» and «Hydrochlorothiazide+Irbesartan»

• Interactions Ibuprofen with Hydrochlorothiazide+Irbesartan

  • Dangerous interactions
    • ⓘ In elderly patients, patients with hypovolemia or patients with impaired renal function, the use of NSAIDs, including COX-2 inhibitors, simultaneously with ARA II, including irbesartan, may lead to deterioration of renal function, including the possible development of acute renal failure.
    • ⓘ It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension.
    • ⓘ As with ACE inhibitors, the combined use of angiotensin II antagonists and NSAIDs may increase the risk of impaired renal function, including the likelihood of acute renal failure, and lead to an increase in serum potassium levels, especially in patients with already impaired renal function.
    • ⓘ In elderly patients, patients with hypovolemia or with impaired renal function, the use of NSAIDs, including COX-2 inhibitors, simultaneously with ARA II, including irbesartan, may lead to deterioration of renal function, including the possible development of acute renal failure.
  • Negative interactions
    • ⓘ Renal function should be periodically monitored in patients taking irbesartan and NSAIDs at the same time.
    • ⓘ With the simultaneous use of ARA II, including irbesartan, and NSAIDs, including selective COX-2 inhibitors, it is possible to weaken the antihypertensive effect of ARA II.
    • ⓘ Ibuprofen reduces the effect of antihypertensive drugs (in pm BCC and ACE inhibitors), natriuretic and diuretic activity of furosemide and hydrochlorothiazide, and the effectiveness of uricosuric drugs.
    • ⓘ Antihypertensive drugs, beta-blockers and diuretics.
    • ⓘ NSAIDs can reduce the antihypertensive effect of antihypertensive drugs, in pm ACE inhibitors, angiotensin II receptor antagonists, beta-blockers and diuretics.
    • ⓘ Diuretics may also increase the risk of nephrotoxic effects of NSAIDs.
    • ⓘ NSAIDs can reduce the diuretic and antihypertensive effects of hydrochlorothiazide.
    • ⓘ NSAIDS: with simultaneous administration of angiotensin II antagonists and NSAIDs (for example, selective COX-2 inhibitors, acetylsalicylic acid > 3 g / day and non-selective NSAIDs), the antihypertensive effect may decrease.
    • ⓘ With the simultaneous use of ARA II and NSAIDs (including selective COX-2 inhibitors), the antihypertensive effect of irbesartan may be weakened.
    • ⓘ Renal function should be regularly monitored in patients taking irbesartan and NSAIDs simultaneously, including selective COX-2 inhibitors.
  • Positive interactions
    • ⓘ Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors and high doses of acetylsalicylic acid (≥3 g/day).
  • Unclear interactions
    • ⓘ NSAIDs, including selective COX-2 inhibitors.
    • ⓘ Inhibitors of the synthesis of endogenous PG (e.g. NSAIDs).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine