Compatibility «Omeprazole» and «Эзомепразол-СЗ»

• Interactions Omeprazole with Эзомепразол-СЗ

  • Negative interactions
    • ⓘ A decrease in the acidity of gastric juice during omeprazole therapy may affect the absorption of antiretroviral drugs.
    • ⓘ Against the background of omeprazole therapy, there is a decrease in serum concentrations of some antiretroviral drugs (atazanavir and nelfinavir).
    • ⓘ Simultaneous use of omeprazole (40 mg once a day with atazanavir 300 mg/ritonavir 100 mg) in healthy volunteers was accompanied by a marked decrease in the bioavailability of atazanavir (AUC, C_max and the minimum plasma concentration (C_min) decreased by about 75%).
    • ⓘ When using omeprazole at a dose of 40 mg, the max and AUC of voriconazole (substrate of the CYP2C19 isoenzyme) increase by 15 and 41%, respectively.
    • ⓘ The use of omeprazole at a dose of 40 mg resulted in an increase in max'>C_max and AUC of cilostazol by 18 and 26%, respectively; for one of the active metabolites of cilostazol, the increase was 29 and 69%, respectively.
    • ⓘ The activity of the thiol metabolite (active metabolite) of clopidogrel was reduced by 46% (day 1 of therapy) and 42% (day 5 of therapy) when taking clopidogrel and omeprazole at the same time.
    • ⓘ When taking clopidogrel and omeprazole at the same time, the average suppression of platelet aggregation (IPA) was reduced by 47% during 24 hours of therapy) and 30% (5th day of therapy).
    • ⓘ According to the results of another study, omeprazole, when used with clopidogreltm, does not simultaneously, at different times, have an inhibitory effect on the CYP2C19 isoenzyme.
    • ⓘ Omeprazole and Esomeprazol belong to the same pharmaceutical group: Proton Pump Inhibitors.
  • No interactions
    • ⓘ It is known about the interaction of omeprazole with some antiretroviral drugs.
    • ⓘ In a clinical study, the interaction of clopidogrel (300 mg loading dose, then 75 mg/ day) with omeprazole (80 mg) was studied simultaneously, at the same time for 5 days.
  • Positive interactions
    • ⓘ Simultaneous administration of omeprazole at a dose of 20 mg once a day and digoxin increases the bioavailability of digoxin by 10% (the bioavailability of digoxin increased by up to 30% in two out of ten patients).
    • ⓘ An increase in the dose of atazanavir to 400 mg did not compensate for the effect of omeprazole on the bioavailability of atazanavir.
    • ⓘ With the simultaneous use of omeprazole with saquinavir, the concentration of saquinavir in the blood serum increases.
  • Unclear interactions
    • ⓘ Given the similar pharmacokinetics and pharmacodynamic properties of omeprazole and esomeprazole, concomitant use of esomeprazole with antiretroviral drugs such as atazanavir and nelfinavir is not recommended.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,027,037 possible combinations of drugs and their components were found 412,563 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-01-01

Category - medicine